OBJECTIVE The aim of this study was to investigate the effect of various C-type natriuretic peptide (CNP) sequences (genomic DNA [CNPDNA], cDNA derived from mRNA [CNPcDNA], and sequence coding for 22 amino acids of the mature CNP [CNP22aa]) on the growth of primary porcine vascular cells. METHODS AND RESULTS Gene transfer was performed with cationic lipid DOCSPER or linear polyethylenimine. A...

A spectral model of luminescence the two-component exciton-activated semiconductor quantum dot (QD) layered plasmon composite nanoparticle (CNP) with a dielectric core and conductive shell in an external magnetic field is constructed, taking into account inhomogeneity quasi-stationary electric generated by QD CNP region, outside framework approximation dipole polarizability CNP. The tensor form...

Lee, Sook Jeong, Sung Zoo Kim, Xun Cui, Suhn Hee Kim, Kyung Sun Lee, Yu Jeong Chung, and Kyung Woo Cho. C-type natriuretic peptide inhibits ANP secretion and atrial dynamics in perfused atria: NPR-B-cGMP signaling. Am. J. Physiol. Heart Circ. Physiol. 278: H208–H221, 2000.— The purpose of the present experiments was to define the role of C-type natriuretic peptide (CNP) in the regulation of atr...

C-type natriuretic peptide (CNP), initially isolated from porcine brain [3], is the most recently characterized member of the natriuretic peptide family. The human CNP gene consists of at least two exons and an intron [4]. Whereas synthesis of atrial and brain natriuretic peptides (ANP and BNP) has been demonstrated mainly in the heart, but also in various other organs [2, 5], CNP m R N A in ma...

Simulation results for optical metamaterials (MTMs) derived from active coated nano-particle (CNP) inclusions for operation in the visible range of the spectrum between 400nm and 700nm are presented. Several examples of optical MTMs designed with these inclusions are characterized, including two-dimensional (2D) CNP metafilms; three-dimensional (3D) periodic CNP arrays; and 3D random CNP distri...

C-type natriuretic peptide (CNP) possesses nitric oxide-like signaling mechanisms and actions in the vasculature, including the inhibition of fibrosis and vascular remodeling through counterregulation of transforming growth factor-β (TGF-β) signaling. The leucine zipper protein transforming growth factor stimulated clone 22 domain 1 (TSC22D1), cloned via its presumed binding to a GC-rich elemen...

We previously reported that C-type natriuretic peptide (CNP) stimulates endochondral ossification and corrects the reduction in body length of achondroplasia model mouse with constitutive active fibroblast growth factor receptor 3 (FGFR-3). In order to examine the interaction between CNP and FGFR-3, we studied intracellular signaling by using ATDC5 cells, a mouse chondrogenic cell line, and fou...

AIMS C-type natriuretic peptide (CNP) and nitric oxide (NO) are endothelium-derived factors that play important roles in the regulation of vascular tone and arterial blood pressure. We hypothesized that NO produced by the endothelial NO-synthase (NOS-3) contributes to the relaxation induced by CNP in isolated rat aorta via activation of endothelial NPR-C receptor. Therefore, the aim of this stu...

Mendonça MC, Koles N, Doi SQ, Sellitti DF. Transforming growth factor1 regulation of C-type natriuretic peptide expression in human vascular smooth muscle cells: dependence on TSC22D1. Am J Physiol Heart Circ Physiol 299: H2018–H2027, 2010. First published August 27, 2010; doi:10.1152/ajpheart.00656.2010.—C-type natriuretic peptide (CNP) possesses nitric oxide-like signaling mechanisms and acti...

Objective-The aim of the present study was to investigate the effects of curcumin nanoparticles (CNP) on stress oxidative following experimental ischemia-reperfusion injury in the rat testes. Design-Experimental Study Animals- Seventy-seven healthy male Wistar rats Procedures-The animals weighing approximately...