نتایج جستجو برای: جهش itd

تعداد نتایج: 4993  

Journal: :Haematologica 2011
Hendrik J M de Jonge Peter J M Valk Eveline S J M de Bont Jan Jacob Schuringa Gert Ossenkoppele Edo Vellenga Gerwin Huls

BACKGROUND High white blood cell count at presentation is an unfavorable prognostic factor for treatment outcome in intermediate cytogenetic risk acute myeloid leukemia. Since the impact of white blood cell count on outcome of subgroups defined by the molecular markers NPMc(+) and FLT3-internal tandem duplication (ITD) is unknown, we addressed this issue. DESIGN AND METHODS We studied the eff...

Journal: :Blood 2008
Li Li Obdulio Piloto Ho Bao Nguyen Kathleen Greenberg Kogo Takamiya Frederick Racke David Huso Donald Small

Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication (ITD) mutations is one of the most common molecular alterations known in acute myeloid leukemia (AML). To investigate the role FLT3/ITD mutations play in the development of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD mutation into the juxtamembrane domain of murine Flt3. FL...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Katherine Tarlock Todd A Alonzo Robert B Gerbing Susana C Raimondi Betsy A Hirsch Lillian Sung Jessica A Pollard Richard Aplenc Michael R Loken Alan S Gamis Soheil Meshinchi

PURPOSE Gemtuzumab ozogamicin (GO), a calicheamicin-conjugated mAb against CD33, has been used in the treatment of acute myeloid leukemia (AML). We evaluated the impact of the addition of GO to standard chemotherapy and hematopoietic stem cell transplant (HCT) in patients withFLT3/ITD. EXPERIMENTAL DESIGN We analyzed children withFLT3/ITD-positive AML (n= 183) treated on two consecutive Child...

Journal: :Journal of physiology, Paris 2004
Catherine E Carr Christine Köppl

In birds and mammals, precisely timed spikes encode the timing of acoustic stimuli, and interaural acoustic disparities propagate to binaural processing centers. The Jeffress model proposes that these projections act as delay lines to innervate an array of coincidence detectors, every element of which has a different relative delay between its ipsilateral and contralateral excitatory inputs. Th...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Zachary M Smith Bertrand Delgutte

Bilateral cochlear implantation attempts to increase performance over a monaural prosthesis by harnessing the binaural processing of the auditory system. Although many bilaterally implanted human subjects discriminate interaural time differences (ITDs), a major cue for sound localization and signal detection in noise, their performance is typically poorer than that of normal-hearing listeners. ...

Journal: :Blood 2012
Nicholas A Zorko Kelsie M Bernot Susan P Whitman Ronald F Siebenaler Elshafa H Ahmed Gabriele G Marcucci Daniel A Yanes Kathleen K McConnell Charlene Mao Chidimma Kalu Xiaoli Zhang David Jarjoura Adrienne M Dorrance Nyla A Heerema Benjamin H Lee Gang Huang Guido Marcucci Michael A Caligiuri

The MLL-partial tandem duplication (PTD) associates with high-risk cytogenetically normal acute myeloid leukemia (AML). Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML. However, mice expressing either Mll-PTD or Flt3-ITD do not develop AML, suggesting that 2 mutations are necessary for the AML phenotype. Thus, we generated a mouse ex...

Journal: :The Journal of the Acoustical Society of America 2016
William M Hartmann Brad Rakerd Zane D Crawford Peter Xinya Zhang

The roles of interaural time difference (ITD) and interaural level difference (ILD) were studied in free-field source localization experiments for sine tones of low frequency (250-750 Hz). Experiments combined real-source trials with virtual trials created through transaural synthesis based on real-time ear canal measurements. Experiments showed the following: (1) The naturally occurring ILD is...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Katrin Vonderschen Hermann Wagner

Birds and mammals exploit interaural time differences (ITDs) for sound localization. Subsequent to ITD detection by brainstem neurons, ITD processing continues in parallel midbrain and forebrain pathways. In the barn owl, both ITD detection and processing in the midbrain are specialized to extract ITDs independent of frequency, which amounts to a pure time delay representation. Recent results h...

2017
Catrin Roolf Nikolaj Dybowski Anett Sekora Stefan Mueller Gudrun Knuebel Andreas Tebbe Hugo Murua Escobar Klaus Godl Christian Junghanss Christoph Schaab

Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. So far, applications of FLT3 small molecule inhibitors have been investigated primarily in FLT3-ITD+ patients. Only recently, a prolonged event-free survival h...

Journal: :Blood 2005
Lara Tickenbrock Joachim Schwäble Markus Wiedehage Björn Steffen Bülent Sargin Chunaram Choudhary Christian Brandts Wolfgang E Berdel Carsten Müller-Tidow Hubert Serve

Activating Flt3 mutations occur in about 30% of patients with acute myeloid leukemia (AML), often as in-frame internal tandem duplication (ITD) at the juxtamembrane domain of the receptor. These mutations transform hematopoietic cell lines and primary mouse bone marrow. Here, we analyzed the interaction between oncogenic Flt3-ITD mutations and the Wingless-type (Wnt) signaling pathway in the my...

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