نتایج جستجو برای: جهش 35delg

تعداد نتایج: 3257  

ابهجی, مریم, اسمیت, ریچارد, بزاز زادگان, نیلوفر, جوان, محمد خلیل, خدایی, حسین, دهقانی, عاطفه, ریاض الحسینی, یاسر, سیفتی, مرتضی, مغنی باشی, مهدی, میراب, محمود, نجم آبادی, حسین, کهریزی, کیمیا,

Introduction: Hearing loss is the most common sensory neural defect in humans, affecting 1 in 1000 neonates, with over half of these cases predicted to be hereditary in nature. Most hereditary hearing loss is inherited in a recessive fashion, accounting for approximately 80 % of non-syndromic hearing loss (NSHL). Mutations in GJB2 gene are major cause of inherited deafness in the European an...

Journal: :International journal of pediatric otorhinolaryngology 2013
Gabrielle N Manzoli Kiyoko Abe-Sandes Alan H Bittles Danniel S D da Silva Luciene da C Fernandes Roberta M C Paulon Iza Cristina S de Castro Carla M C A Padovani Angelina X Acosta

OBJECTIVE There are many hearing impaired individuals in Monte Santo, a rural municipality in the state of Bahia, Brazil, including multiple familial cases strongly suggestive of a genetic aetiology. METHODS The present study investigated 81 subjects with hearing impairment (HI) recruited from 36 families. Mutations often associated with HI, i.e. the DFNB1 mutations c.35delG in GJB2, deletion...

Journal: :Ear and hearing 2009
Ana Carla Batissoco Ronaldo Serafim Abreu-Silva Maria Cristina Célia Braga Karina Lezirovitz Valter Della-Rosa Tabith Alfredo Paulo Alberto Otto Regina Célia Mingroni-Netto

OBJECTIVE Hereditary nonsyndromic deafness is an autosomal recessive condition in about 80% of cases, and point mutations in the GJB2 gene (connexin 26) and two deletions in the GJB6 gene (connexin 30), del(GJB6-D13S1830) and del(GJB6-D13S1854), are reported to account for 50% of recessive deafness. Aiming at establishing the frequencies of GJB2 mutations and GJB6 deletions in the Brazilian pop...

Mutations in the connexin 26 (Cx26) gene at the DFNB1 locus on chromosome 13q12 are associated with autosomal recessive non-syndromic hearing loss (ARNSHL). There are many known mutations in this gene that cause hearing loss. A single frameshift, at position 35 (35delG) accounts for 50% of mutations in the Caucasian population with carrier frequencies of 1.5-2.5%. In this study we investigated ...

Journal: :General physiology and biophysics 2003
G Minárik V Ferák E Feráková A Ficek H Poláková L Kádasi

Mutations in the GJB2 gene (connexin 26) represent a major cause of autosomal recessive non-syndromic hearing loss (NSHL) worldwide. In most Caucasian populations, the 35delG mutation in this gene was found to account for up to 50% of cases of the genetic non-syndromic childhood deafness. In populations of non-European ethnic background, other GJB2 gene mutations are occasionally common, e.g. 1...

Journal: :The Turkish journal of pediatrics 2005
Burcu Balci Filiz Ozbaş Gerçeker Songül Aksoy Gonca Sennaroğlu Ersan Kalay Levent Sennaroğlu Pervin Dinçer

Mutations in the GJB2 gene have been shown to be the major cause of autosomal recessively inherited, prelingual, non-syndromic hearing loss. 35delG was found to be the most frequent mutation among Caucasians. In this study, we performed haplotype analysis of two large families with autosomal recessive non-syndromic hearing loss (totally 33 affected, 37 unaffected) from Trabzon (a city from the ...

2012
Joana Rita Chora Helena Simões-Teixeira Tiago Daniel Matos Jorge Humberto Martins Marisa Alves Raquel Ferreira Luís Silva Carlos Ribeiro Graça Fialho Helena Caria

Individual's hearing performance after cochlear implant (CI) is variable and depends on different factors such as etiology of deafness, age at implantation, and social/family hearing environment. Here we report the case of dizygotic twins, boy and girl, presenting with neurosensorial profound deafness prior CI (age of implantation = 3.5 years old). Both parents have severe/profound deafness, si...

ابراهیمی, احمد, حبیبی, هاله, نجم آبادی, حسین, استادی, فرزانه , اسمیت, آرـ جی ـ اچ , شفقتی, یوسف , محسنی, مرضیه , پورجعفری, حمید ,

Introduction & Objective : Hearing loss is the most prevalent form of sensory impairment in humans, affecting approximately one in 1000 infants. In more than half of the cases, the deafness is inherited, and about 80% of hereditary deafness transmitted by autosomal recessive pattern. In hereditary congenital deafness, numerous mutations in GJB2 make the largest fractional contribution in many w...

Journal: :JAMA 1999
G E Green D A Scott J M McDonald G G Woodworth V C Sheffield R J Smith

CONTEXT Mutations in the GJB2 gene are the most common known cause of inherited congenital severe-to-profound deafness. The carrier frequency of these mutations is not known. OBJECTIVES To determine the carrier rate of deafness-causing mutations in GJB2 in the midwestern United States and the prevalence of these mutations in persons with congenital sensorineural hearing loss ranging in severi...

Journal: :Genetic testing and molecular biomarkers 2009
Mortaza Bonyadi Mohsen Esmaeili Masoumeh Abhari Alireza Lotfi

AIMS Mutations in the GJB2 gene-encoding connexin 26 protein are the main cause for autosomal recessive nonsyndromic hearing loss worldwide. In this study, we assessed the contributions made by GJB2 and del(GJB6-D13S1830) mutations to the autosomal recessive nonsyndromic deafness genetic load in Iranian Azeri Turkish patients. RESULTS Probands from 209 different nuclear families were investig...

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