BACKGROUND CARP-1/CCAR1, a perinuclear phospho-protein, regulates signaling by adriamycin, steroids, or growth factors. However, intracellular events that regulate CARP-1-dependent cell growth are not fully understood. RESULTS Here we investigated whether CARP-1 is involved in signaling induced by the protein kinase A inhibitor H89. Treatments of human breast cancer cells with H89 resulted in...

Analysis of mechanical systems is based on Newton’s laws of motion. Usually, ideal (or point) masses are considered in the analysis, as shown in the Figure 1. Motion is considered with respect to a non-accelerating reference frame, usually a fixed point on earth or another non-accelerating object. The equation of motion for a mass m(t) is based on Newton’s second law which expresses the conserv...

We announce our successful computation of a list of representatives of the conjugacy classes of subgroups of Sn for n ≤ 18, including the 7 274 651 classes of subgroups of S18.

To understand the molecular mechanism of ligand-induced gating of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)/Ca(2+) release channel, we analyzed the channel properties of deletion mutants retaining both the IP(3)-binding and channel-forming domains of IP(3)R1. Using intrinsically IP(3)R-deficient cells as the host cells for receptor expression, we determined that six of the muta...

stituent of marijuana, Cannabis sativa L. It is well known that THC is oxidized to a number of metabolites in the liver of mammals. Recent studies have clarified that P450 plays a major role in the oxidation of THC. We have previously reported that a hepatic microsomal enzyme, named microsomal alcohol oxygenase (MALCO), is able to oxidize 7aand 7b-hydroxy-D-THC to 7-oxo-D-THC in the presence of...

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