Localization of Paracentrotus lividus bep maternal mRNAs at the animal pole occurs by association with the cytoskeleton and involves a 54-kDa protein, called LP54, that is able to bind to the 3' untranslated regions (UTRs) of bep mRNAs. We describe here the isolation and purification of this protein. Antibodies raised against purified LP54 allowed us to establish its localization in P. lividus ...

A simple model to estimate the bit error probability (BEP) for a digital radio receiver, co-located with an undesired radiated interference source, is proposed. Co-location is defined as the area around the receiver (radius r), where an interferer has a significant impact on the BEP. The interference source is approximated to be of Gaussian type. A comparison of the emission limits given in Eur...

BACKGROUND This Australian single-arm, multicenter, phase II trial evaluated feasibility, tolerability and activity of accelerated bleomycin, etoposide and cisplatin (BEP) as first-line chemotherapy for metastatic germ cell tumours. PATIENTS AND METHODS Patients were planned to receive cisplatin 20 mg/m(2) and etoposide 100 mg/m(2) days 1-5, and pegfilgrastim 6 mg day 6, all repeated every 2 ...

To the Editor: Trauma-focused cognitive-behavioral therapy (CBT) and eye movement desensitization and reprocessing are empirically supported treatments for posttraumatic stress disorder (PTSD).1 However, dropout rates from CBT studies are usually around 20%; up to 58% of patients who completed CBT are still diagnosed with PTSD at posttreatment assessment. Furthermore, only 32%–66% of patients a...

Young males have testicular germ cells tumors (TGCT) as the most common malignancy and its incidence is increasing in several countries. Besides unilateral orchiectomy (UO), the treatment of TGCT may include surveillance, radiotherapy, or chemotherapy (CT), basing on tumor histology and stage of disease. It is well known that both radio and CT may have negative effects on testicular function, a...

Our initial studies with cisplatin + vinblastine + bleomycin began 27 years ago in 1974, changing the cure rate for disseminated disease from 5 to 60%. Subsequently, through random prospective clinical trials, we have modified the treatment regimen to reduce both the duration and dosages of the chemotherapy drugs. Cisplatin + etoposide was first used at Indiana University as salvage chemotherap...

PURPOSE To review the outcome for all patients with ovarian dysgerminoma treated at the M.D. Anderson Cancer Center who received bleomycin, etoposide, and cisplatin (BEP) and to assess the menstrual and reproductive function of those who received conservative treatment. PATIENTS AND METHODS Clinical information was abstracted from the medical record. Patients completed a detailed questionnair...

3-Benzyl-3-ethyl-2-piperidinone (3-BEP) belongs to a family of compounds that includes alpha- substituted gamma-butyrolactones, gamma-thiobutyrolactones, 2-pyrrolidinones and hexahydro-2H-azepin-2-ones. Many of these drugs exhibit potent in vivo anticonvulsant activity in mice. Previous electrophysiological studies demonstrated that they potentiate gamma-aminobutyric acid- (GABA) mediated chlor...

Benign Prostatic Hyperplasia (BPH) is a major health problem for male above 50 years and increasing of age. It leads to different lower urinary tract problems including urgency, frequency, incomplete voiding and residual urine, recurrent Urinary tract Infection(UTI) etc and may even progress to prostatic cancer in some cases. The major cause of this BEP is proliferation of prostate smooth muscl...

Recently, cooperative communication have attracted significant attention to tackle the limitations imposed by multiple-input-multiple-output (MIMO) technology. To eliminate these limitations and increase spectral efficiency, best relay selection technique was proposed. In this paper, the performance of a new hybrid relay selection protocol is investigated. In particular, closedform expressions ...