District heating and cooling (DHC) systems have been actively introduced as energy supply systems in urban areas. Since there exist a number of large-size freezers, heat exchangers and boilers in a DHC plant to generate and supply cold water, hot water and steam to a DHC system, the control under an operation plan for these instruments on the basis of the demand of cold water, hot water and ste...

The rodent hippocampus can be divided into dorsal (DHC) and ventral (VHC) domains on the basis of behavioral, anatomical, and biochemical differences. Recently, we reported that CA1 pyramidal neurons from the VHC were intrinsically more excitable than DHC neurons, but the specific ionic conductances contributing to this difference were not determined. Here we investigated the hyperpolarization-...

Traditional methods of therapeutic hypothermia show promise for neuroprotection against cerebral ischemia-reperfusion (I/R), however, with limitations. We examined effectiveness and specificity of pharmacological hypothermia (PH) by transient receptor potential vanilloid 1 (TRPV1) channel agonism in the treatment of focal cerebral I/R. Core temperature (T(core)) was measured after subcutaneous ...

This article is available online at http://www.jlr.org Smith-Lemli-Opitz syndrome (SLOS) is a metabolic disorder resulting from mutations in the gene encoding 7-dehydrocholesterol reductase (DHCR7), the enzyme that catalyzes the reduction of 7-dehydrocholesterol (7-DHC) to cholesterol (Chol) ( 1–7 ). Elevated levels of 7-DHC and reduced levels of Chol are observed in tissues and fl uids of pati...

The complexation behavior of palmatine (P) and dehydrocorydaline (DHC) alkaloid guest molecules by cucurbit[7]uril (CB7) host have been investigated by means of fluorescence spectra in aqueous phosphate buffer solution (pH 7.2). It is found that each alkaloid exhibits dramatic fluorescence enhancement upon complexation with CB7, and the intensity of the emittance is strong enough to be readily ...

Sirtuins are a family of phylogenetically conserved nicotinamide adenine dinucleotide-dependent deacetylases that have a firmly established role in aging. Using a simple Saccharomyces cerevisiae yeast heterochromatic derepression assay, we tested a number of environmental chemicals to address the possibility that humans are exposed to sirtuin inhibitors. Here we show that dihydrocoumarin (DHC),...

Capsaicin (CAP), the pungent principle from chilli peppers, has shown various activities such as analgesic, anticancer and antioxidant. To further explore a therapeutic application of this compound, several derivatives of CAP were designed and synthesized. Starting materials, CAP and dihydrocapsaicin (DHC), were obtained as a mixture from dried fruits of Capsicum annuum sp. in 0.069 % yield. St...

The movements of cilia and flagella are driven by multiple species of dynein heavy chains (DHCs), which constitute inner- and outer-dynein arms. In Chlamydomonas, 11 DHC proteins have been identified in the axoneme, but 14 genes encoding axonemal DHCs are present in the genome. Here, we assigned each previously unassigned DHC gene to a particular DHC protein and found that DHC3, DHC4 and DHC11 ...

OBJECTIVES A preliminary study to investigate the orthodontic treatment need and its gender distribution in urban Iranian schoolchildren. STUDY DESIGN A cross-sectional study was carried out at the school premises. SUBJECTS AND METHODS For this survey, 502 subjects attending 6 different schools in the city of Isfahan, Iran (253 females and 249 males, aged 11-14 years) were randomly selected...

DHC-1, a herbal formulation, was tested for its anti-ulcer and antioxidant activity in rats. Effect of various doses (125, 250, 500, and 1000 mg/kg, p.o.) of DHC-1 was studied on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol-induced gastric mucosal injury in rats. The reduction in ulcer index in both the models along with the reduction in volume and total acidity, and ...