Cyclin A2 plays a key role in cell cycle regulation. It is essential in embryonic cells and in the hematopoietic lineage yet dispensable in fibroblasts. In this paper, we demonstrate that Cyclin A2-depleted cells display a cortical distribution of actin filaments and increased migration. These defects are rescued by restoration of wild-type Cyclin A2, which directly interacts with RhoA, or by a...

OBJECTIVES Leishmania can lead to a broad spectrum of diseases, collectively known as leishmaniasis. The A2 gene/ protein family could be one of the most eligible candidate factors of virulence in visceral leishmaniasis (VL). The previous results confirmed that in Leishmania infantum, several A2 proteins are abundantly expressed by the amastigote, but not the promastigote stage. As there are no...

PURPOSE Annexin A2 has been shown to play a role in many neovascularization diseases. We investigated the effect of vascular endothelial growth factor (VEGF) on annexin A2 expression and related intracellular signaling mechanisms in a mouse model of ischemia-induced retinal neovascularization. METHODS Annexin A2 expression and the effect of vascular endothelial growth factor (VEGF) on annexin...

Background and Aims: This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene. Materials and Methods: The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were descri...

Tungsten is considered as a primary material for the divertor and first wall in many fusion reactor designs. There has been further interest nano-structured multi-phase tungsten alloys composites, such oxide dispersion strengthened alloys, where interfaces may be harnessed defect sinks to improve irradiation resilience, whilst also improving base mechanical strength, potentially ductility. Here...

Many studies highlighted potential associations of β-casein A1 with specific human diseases and a minor digestibility milk, due to the bioactive peptide β-casomorphin 7 (BCM-7) release during digestion. Conversely, ancestral A2 variant seems be favorable trait because it is not associated BMC-7 release. The aim this work was evaluate frequencies variants in offspring previously genotyped cows i...

Hemoglobin A2 (Hb A2) and hemoglobin F (Hb F) are important analytes in the diagnosis and follow up of Hb diseases. We evaluated a new capillary zone electrophoresis (CZE) kit for Hb A2 and Hb F measurements. The imprecision ranged from 3% to 6% for Hb A2 and Hb F at physiological and pathological concentrations. The method compared well with cation-exchange HPLC for Hb A2 and Hb F and with ani...

Done all A–1 Determine, with proof, the number of ordered triples (A1, A2, A3) of sets which have the property that (i) A1 ∪A2 ∪A3 = {1, 2, 3, 4, 5, 6, 7, 8, 9, 10}, and (ii) A1 ∩A2 ∩A3 = ∅. Express your answer in the form 2357, where a, b, c, d are nonnegative integers. Solution: For each integer i from 1 to 10 you must put i in one of 6 sets: A1 ∩ A2 ∩ A3 or A1 ∩ A2 ∩ A3 or A1 ∩ A2 ∩ A3 or A1...

The von Willebrand factor (VWF) A2 crystal structure has revealed the presence of a rare vicinal disulfide bond between C1669 and C1670, predicted to influence domain unfolding required for proteolysis by ADAMTS13. We prepared VWF A2 domain fragments with (A2-VicCC, residues 1473-1670) and without the vicinal disulfide bond (A2-DeltaCC, residues 1473-1668). Compared with A2-DeltaCC, A2-VicCC ex...

Previous studies have shown that influenza virus-immune cytotoxic T lymphocytes can recognize virus in conjunction with self HLA-A2 antigens. Nevertheless, the virus-infected target cells from one HLA-A2-positive male donor (designated M7) could not be lysed by the virus-immune cytotoxic lymphocytes from any HLA-A2-matched unrelated donors. Although extensive serological analyses showed no diff...