Four native Papaver species of Iran, i. e. P. glaucum, P. tenuifolium, P. dubium and P. fugax, were collected from their natural habitat and subjected to HPLC analysis for determination of their morphine, codeine and thebaine content. P. dubium and R. glaucum contained all of the three mentioned narcotic alkaloids, while morphine was not found in P. fugax, and P. tenuifolium was free from codeine.

Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver som...

papaverfugax poiret population tarom was shown to contain one major alkaloid, mecamberine (0.4%), and six minor alkaloids, roemerine, pronuciferine, protopine, thebaine, nornuciferine and salutaridine. nornuciferine was detected for the first time in p. fugax

The research was conducted with the aim of examining alkaloids content twelve poppies (Papaver somniferum L.) cultivars registered in Turkey by correlation and path analysis relationships among capsule yield. field experiments were set up according to a randomized complete block design three replications 2017-18 2018-19 under semi-arid ecological conditions Isparta, Turkey. differences yields a...

It has been firmly established that humans excrete a small but steady amount of the isoquinoline alkaloid morphine in their urine. It is unclear whether it is of dietary or endogenous origin. There is no doubt that a simple isoquinoline alkaloid, tetrahydropapaveroline (THP), is found in human and rodent brain as well as in human urine. This suggests a potential biogenetic relationship between ...