Computer Aided Aroma Design (CAAD) is likely to become a hot issue as the REACH EC document targets many aroma compounds to require substitution. The two crucial steps in CAMD are the generation of candidate molecules and the estimation of properties, which can be difficult when complex molecular structures like odours are sought and when their odour quality are definitely subjective whereas th...

The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary markedly within genotypes and were, therefore, expected to add to the informativeness of genotype for predicting vascular disease. The case-control sample included 212 age- and race-matched men (mean age 66.4 years). The 106 carotid artery...

This paper outlines some roles of knowledge while designing based on experimental results from studying novice and expert designers. The implications of these experimental results on future CAAD systems are discussed.

Isomer-specific 3-chloroacrylic acid dehalogenases catalyze the hydrolytic dehalogenation of the cis- and trans-isomers of 3-chloroacrylate to yield malonate semialdehyde. These reactions represent key steps in the degradation of the nematocide, 1,3-dichloropropene. The kinetic mechanism of cis-3-chloroacrylic acid dehalogenase (cis-CaaD) has now been examined using stopped-flow and chemical-qu...

In the past, conventional computer-aided architectural design (CAAD) systems could not manage semantic information on building components and spaces but only graphical and geometric information. However, since the advent of Building Information Modeling (BIM), which has been used for managing semantic building information, determining spatial relationships as well as quantities and properties o...

The focus of this paper is the implementation of web-based data platforms for CAAD research and education. This review is based on three case studies that use different software environments for the creation of the specified data platforms: eCAADe/FileMakerdatabases, ACADIA/CAMEO-WebObjects environment and SciX/WODA-language.

GCN4 is a transcriptional activator in the bZIP family that regulates amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. The N-terminal 100 amino acids of GCN4 contains a potent activation function that confers high-level transcription in the absence of the centrally located acidic activation domain (CAAD) delineated in previous studies. To identify specific amino acids import...

ion.