Inner ear sensory hair cells (HCs), supporting cells (SCs), and sensory neurons (SNs) are hypothesized to develop from common progenitors in the early embryonic otocyst. Because little is known about the molecular signals that control this lineage specification, we derived a model system of early otic development: conditionally immortalized otocyst (IMO) cell lines from the embryonic day 9.5 Im...

Early life stress (ELS) induces long-term effects in later functioning and interacts with further exposure to other stressors in adulthood to shape our responsiveness to reward-related cues. The attribution of incentive salience to food-related cues may be modulated by previous and current exposures to stressors in a sex-dependent manner. We hypothesized from human data that exposure to a traum...

This paper reviews current problems in intact stability criteria, including the development of new generation intact stability criteria at the IMO (International Maritime Organization), the activities of the ITTC(International Towing Tank Conference) ‘s Specialist Committee on Stability in Waves (SiW) and relevant international researches as the backgrounds of the SCAPE Committee (Strategic Res...

This paper assesses the performance of mobile messaging and VoIP connections. We investigate the CPU requirements of WhatsApp and IMO under different scenarios. This analysis also enabled a comparison of the performance of these applications on two Android operating system (OS) versions: KitKat or Lollipop. Two models of smartphones were considered, viz. Galaxy Note 4 and Galaxy S4. The applica...

The aim of this longitudinal observational study was to evaluate the oral health-related quality of life (OHRQoL) following patient rehabilitation with implant-retained mandibular overdentures (IMO) and to identify the contribution of the different domains to OHRQoL. The Oral Health Impact Profile (OHIP-EDENT), Dental Impact on Daily Living (DIDL), and Geriatric Oral Health Assessment Index (GO...

Previously we demonstrated that calmodulin binds to the carboxy terminus of Spc110p, an essential component of the Saccharomyces cerevisiae spindle pole body (SPB), and that this interaction is required for chromosome segregation. Immunoelectron microscopy presented here shows that calmodulin and thus the carboxy terminus of Spc110p localize to the central plaque. We created temperature-sensiti...

Ingredients delivering functional and nutritional benefits are of interest to food manufacturers. Isomaltooligosaccharides (IMOs) which serve as alternate sweeteners fit into this category. IMOs are a mixture of α-(1 → 6) and α-(1 → 4)-linked glucose oligomers, synthesized by an enzymatic reaction from starch (corn, tapioca). The aim of this study was to evaluate the fermentability and glycemic...

The hormonal changes associated with immobilization stress (IMO) include a swift increase in corticosterone (CORT) concentration and a decrease in circulating testosterone (T) levels. There is evidence that the production of the short-lived neuromodulator nitric oxide (NO) is increased during stress in various tissues, including the brain. NO also suppresses the biosynthesis of T. Both the indu...

هدف پژوهش حاضر، طراحی و اعتباریابی برنامه فرزندپروری بالنده به‌منظور ایجاد آرامش در خانواده‌های دارای فرزند کم‌شنوا بود. این بر اساس از نوع بنیادی نظر ماهیت گرد‌آوری داده‌ها کیفی است. دو گام نخست با روش تحلیل محتوا، سه بعدی استفاده نظریه داده‌بنیاد گام‌های دلفی انجام شد. جامعه آماری حاضر شامل متخصصان روان‌شناسی آموزش کودکان کم‌شنوا، معلمان کم‌شنوای پیش‌دبستانی مادران نمونه پنج متخصص، معلم پانزد...