BACKGROUND Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies. OBJECTIVE To determine the presence or levels of antibodies (Abs) against matrix metalloproteinase (MMP)-1 and their clinical relevance in LSc. METHODS Anti-MMP-1 Ab was examined by ELISA (Enzyme-Linked ImmunoSorbent Assay) and immunoblotting using human recombinant MMP-1. MMP-1 collage...

Eighty crossbred, virgin, yearling beef bulls were subjected to three serving capacity (SC) tests. Ten low SC (LSC) and 10 high SC (HSC) bulls similar in weight (avg wt = 452 kg), testicular size and seminal traits but differing in average services were selected. Objectives were to evaluate the mating behavior and fertility of LSC and HSC bulls at pasture when exposed to an average and a heavy ...

We investigate the effect of weak rotation on the large-scale circulation (LSC) of turbulent Rayleigh-Bénard convection, using the theory for cessations in a low-dimensional stochastic model of the flow previously studied. We determine the cessation frequency of the LSC as a function of rotation, and calculate the statistics of the amplitude and azimuthal velocity fluctuations of the LSC as a f...

INTRODUCTION Laparoscopic subtotal cholecystectomy (LSC) is a widely used technique for managing cholelithiasis with severe cholecystitis. The increasing popularity its utilization is due to the good safety profile and acceptable results. This case series evaluates the short- and long-term results of Indonesian patients who underwent LSC with an objective to determine whether the procedure can ...

Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells (LSC) have also indicated heterogeneity of these cells. On the basis of mathematical modeling and computer simulations, we have provided evidence that proliferation and self-renewal rates of the LSC population have great...

Acute myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy, which is initiated and driven by a rare fraction of leukemia stem cells (LSCs). Despite the difficulties of identifying a common LSC phenotype, there is increasing evidence that high expression of stem cell gene signatures is associated with poor clinical outcome. Identification of functionally distinct subpopul...

Mechanized generation of prototypes from high-level specifications has long been an ultimate challenge for software engineering. One high-level specification of great interest is scenario-based sequence diagrams. Sequence diagrams serve as the manifestation of use cases and if synthesizable they could lead directly to implementation. In this work, we propose a method to generate prototypes all ...

INTRODUCTION The aim of this study was the comparison of 24h urine free cortisol (UFC), serum cortisol at 11pm (SCM) and late-nightsalivary cortisol (LSC) in patients suspected for hypercortisolism, and an assessment of the usefulness of these measurements in diagnosingovert Cushing's (OCS) syndrome, pseudo Cushing's state (PCS) and subclinical Cushing's syndrome (SCS). MATERIAL AND METHODS T...

To identify the effective region of the pons in response to inaperisone which facilitates urine storage, inaperisone (100 mM, 0.2 microliters) was injected into the nucleus locus coeruleus alpha (LCa, the pontine micturition center), the nucleus locus subcoeruleus (LSC, the pontine urine storage center) and the nucleus reticularis pontis oralis (PoO, micturition inhibitory region) of the decere...

Previously we published a dynamical model E. Brown and G. Ahlers, Phys. Fluids 20, 075101 2008 for the large-scale-circulation LSC dynamics of Rayleigh–Bénard convection in cylindrical containers. The model consists of a pair of stochastic ordinary differential equations, motivated by the Navier–Stokes equations, one each for the strength and the orientation 0 of the LSC. Here we extend it to c...