نتایج جستجو برای: ایزوفرمهای مسیر pi3k
تعداد نتایج: 45391 فیلتر نتایج به سال:
سرطان پستان شایعترین نوع سرطان در زنان در سراسر جهان میباشد و استروژنها و گیرندههای استروژنی نقش مهم در اتیولوژی این نوع سرطان دارند. شیمیدرمانی، پرتودرمانی، جراحی و هورموندرمانی درمانهای رایج سرطان پستان محسوب می شوند. مشکل عمده درمانهای فعلی، عوارض جانبی متعدد از جمله آسیب به سلولهای سالم بدن، مقاومت به دارو و عود مجدد بیماری است. بنابراین دستیابی به راهکارهای درمانی جدید با سمیت و...
Objective(s): The aim of this study was to investigate the effect of curcumin on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its underlying potential mechanism.Materials and Methods: The tissue explant adherence method was used to isolate hPDLSCs. Flowcytometry, Alizarin Red staining and Oil Red ...
Background: Aberrant pre-mRNA alternative splicing is a common event in cancer cells. Many abnormally spliced RNA variants have been observed in tumor cells and they can be used as biomarkers or therapeutic targets in new drug design. Increasing our knowledge in understanding the mechanisms of alternative pre-mRNA splicing for cancer-related genes and determination of cancer specific isoforms a...
Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of eupafolin on LPS-induced cardiomyocyte autophagy...
مقدمه: مسیر PI3K/Akt/mTOR در ایجاد مقاومت به درمان هورمونی بیماران مبتلا به سرطان پستان از اهمیت به‌سزایی برخوردار است. یکی از اجزای تنظیم‌کننده این مسیر، ژن PTEN میباشد. مطالعه حاضر با هدف مقایسه بروز ژن PTEN در بیماران سرطان پستان با گیرنده استروئیدی مثبت در دو گروه بیماران حساس و مقاوم به تاموکسیفن انجام شد. روش‌کار: این مطالعه مقطعی و گذشته‌نگر بر روی 80 نفر از بیماران مبتلا به سرطان پستا...
Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway
Gastric cancer is one of the most common malignancies with a high mortality rate world. This study intends to make clear role and mechanism Scutellarin (Scu), flavonoid isolated from Erigeron breviscapus (Vant.) Hand.-Mazz, in regulating evolvement gastric cancer. We selected different doses Scu treat cells (MGC-803 AGS). Then, cell counting kit-8 (CCK8) assay was conducted verify proliferation...
Background & Aims: Common nutritional mistakes cause inflammation and homeostasis disruption in heart cells. Inflammasome complex is one of the pathways that induces inflammation and degradation of cardiac protein regeneration. The aim of the present study was to investigate changes in NLRP1inflammasome, PI3k, apoptosis, and histopathology of heart tissue following aerobic physical activity and...
This study aims to explore the cytotoxic, apoptotic and autophagic effects of thymoquinone on human acute myeloid leukemia. The cytotoxic were determined with 3-(4, 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT) tests. B-cell lymphoma 2 associated X protein (Bax), (Bcl-2), caspase 3, mammalian target rapamycin (mTOR), phosphatidylinositol-3-kinase (PI3K), kinase B (AKT) gene expr...
The lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. However in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. The metastasis of lung cancer is highly dependent of expression of matrix me...
Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of several factors contributing to PD prognosis, the role of p38 MAPKs (mitog...
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