Compartmentalisation is a defining feature of eukaryotic life. Effective communication between organelles is essential for cell maintenance, growth and response to external stimuli. Static snapshots provided through ultrastructural studies of preserved tissue highlight that certain organelles are in intimate contact at membrane contact sites (MCSs), also referred to as inter-organellar tetherin...

On 20–22 July 2012, a severe rainstorm occurred in the Sichuan basin of Southwest China and Beijing area North China. This was related to activities Tibetan Plateau vortex (TPV) (SWCV). By using radiosonde, satellite brightness temperature, NCEP_FNL data, we investigated helicity characteristics nearly vortexes their effect on convection. Results showed that (1) strong precipitation mainly inte...

Abstract Convective vertical transport is critical in the monsoonal overturning, but relative roles of different convective systems are not well understood. This study used a cloud classification and tracking technique to decompose convection-permitting simulation South Asian summer monsoon (SASM) into subregimes mesoscale (MCSs), non-MCS deep convection (non-MCS), congestus, shallow convection...

The changes in extreme rainfall associated with a warming climate have drawn significant attention in recent years. Mounting evidence shows that sub-daily convective rainfall extremes are increasing faster than the rate of change in the atmospheric precipitable water capacity with a warming climate. However, the response of extreme precipitation depends on the type of storm supported by the met...

Problem of pattern recognition is accompanying our whole life, therefore methods of automatic pattern recognition is one of the main trend in Artificial Intelligence. Multiple classifier systems (MCSs) are currently the focus of intense research. In this conceptual approach, the main effort is concentrated on combining knowledge of the set of individual classifiers. Proposed work presents a bri...

In this paper we describe a high-performance multicompartment stochastic simulator called mcss which we have developed and are using to execute large-scale systems biology models. Our eventual goal is to be able to simulate multiscale systems biology models containing millions of compartments each of them hosting large biological regulatory networks. We show that mcss is able to accurately and ...

Membrane contact sites (MCSs) allow the exchange of molecules and information between organelles, even when their membranes cannot fuse directly. In recent years, a number of functions have been attributed to these contacts, highlighting their critical role in cell homeostasis. Although inter-organellar connections typically involve the endoplasmic reticulum (ER), we recently reported the prese...

Proliferating Mobile Crowdsensing Systems (MCSs) is a promising paradigm to realize large-scale sensing targets in an agile and economical manner. Privacy protection mechanisms, which alleviate mobile user’s concern on participating MCS tasks, also introduce the issue of data quality to the MCS server. In privacy-preserving MCSs, dishonest reporting of mobile sensing data from task participants...

Inhibition of dimerization to the active form of the HIV-1 aspartic proteinase (HIV-1 PR) may be a way to decrease the probability of escape mutations for this viral protein. The Multiple Copy Simultaneous Search (MCSS) methodology was used to generate functionality maps for the dimerization interface of HIV-1 PR. The positions of the MCSS minima of 19 organic fragments, once postprocessed to t...

Inter-organelle membrane contacts sites (MCSs) are specific subcellular regions favoring the exchange of metabolites and information. We investigated the potential role of the late-endosomal membrane-anchored proteins StAR related lipid transfer domain-3 (STARD3) and STARD3 N-terminal like (STARD3NL) in the formation of MCSs involving late-endosomes (LEs). We demonstrate that both STARD3 and ST...