The genome of eukaryotes is organized into structural units of chromatin loops. This higher order organization is supported by a nuclear skeleton called the nuclear matrix. The genomic DNA associated with the nuclear matrix is called the matrix associated region (MAR). Only a few genome-wide screens have been attempted, although many studies have characterized locusspecific MAR DNA sequences. I...

AIM To compare a novel, fully synthetic, polyurethane based glue (MAR-1) to fibrin sealant in a partial liver resection rat model. METHODS After 50% resection of the lateral left liver lobe in male Wistar rats (n = 7/group/time point), MAR-1, Fibrin or NaCl was applied. After 14, 21 and 90 postoperative days, sealant degradation, intra-abdominal adhesions were scored, and histological examina...

In order to understand the role of the mar locus in Salmonella with regard to multiple antibiotic resistance, cyclohexane resistance, and outer membrane protein F (OmpF) regulation, a marA::gfp reporter mutant was constructed in an antibiotic-sensitive Salmonella enterica serovar Typhimurium DT104 background. Salicylate induced marA, whereas a number of antibiotics, disinfectants, and various g...

Scaffold/matrix-associated region (S/MAR) sequences are DNA regions that are attached to the nuclear matrix, and participate in many cellular processes. The nuclear matrix is a complex structure consisting of various elements. In this paper we compared frequencies of simple nucleotide motifs in S/MAR sequences and in sequences extracted directly from various nuclear matrix elements, such as nuc...

Teff, Karen L., Abass Alavi, Jergin Chen, Michael Pourdehnad, and Raymond R. Townsend. Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R707–R714, 1999.—We compared the vagal contribution to gastric emptying in lean and obese subjects by monitoring gastric emptying of a meal during...

Billington, Charlotte K., Sunil K. Joseph, Caroline Swan, Mark G. H. Scott, Timothy M. Jobson, and Ian P. Hall. Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L412–L419, 1999.— Elevation in cell cAMP content can inhibit mitogenic signaling in cultured human airway smooth muscle (HASM) cells. We st...

Watts, Stephanie W., and Gregory D. Fink. 5-HT2Breceptor antagonist LY-272015 is antihypertensive in DOCAsalt-hypertensive rats. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H944–H952, 1999.—We previously demonstrated a change in the receptors mediating 5-hydroxytryptamine (5-HT)-induced contraction in arteries of deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Specifically, contra...

Ray, Ramesh M., Barbara J. Zimmerman, Shirley A. McCormack, Tarun B. Patel, and Leonard R. Johnson. Polyamine depletion arrests cell cycle and induces inhibitors p21Waf1/Cip1, p27Kip1, and p53 in IEC-6 cells. Am. J. Physiol. 276 (Cell Physiol. 45): C684–C691, 1999.—The polyamines spermidine and spermine and their precursor putrescine are intimately involved in and are required for cell growth a...

Hardt, Stefan E., Armin Just, Raffi Bekeredjian, Wolfgang Kübler, Hartmut R. Kirchheim, and Helmut F. Kuecherer. Aortic pressure-diameter relationship assessed by intravascular ultrasound: experimental validation in dogs. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1078– H1085, 1999.—Intravascular ultrasound (IVUS) has emerged as an important diagnostic method for evaluating vessel diameter...

Marples, David, Jørgen Frøkiaer, and Søren Nielsen. Long-term regulation of aquaporins in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F331–F339, 1999.—The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct w...