Irinotecan, a standard of care therapy for CRC, elicits cytotoxic effects by generating double strand breaks resulting in DNA damage. The activation of the ATM pathway plays a fundamental role in regulating the cellular response and repair to DNA damage. The objective of this preclinical study was to determine whether ATM inhibition would enhance sensitivity to irinotecan treatment. Treatment e...

Possible relations between the native oxide film formed spontaneously on the AZ31 and AZ61 magnesium alloy substrates with different surface finish, the chemistry of the outer surface of the conversion coatings that grows after their subsequent immersion on saturated aqueous NaHCO₃ solution treatment and the enhancement of corrosion resistance have been studied. The significant increase in the ...

Twin-roll casting AZ31 Mg alloy sheets have been fabricated by normal unidirectional-rolling, head-to-tail rolling, and clock-rolling, respectively. It has been demonstrated that head-to-tail rolling is the most effective to refine the microstructure and weaken the basal texture among the three rolling routes. Excellent integrated tensile properties can be obtained by the head-to-tail rolling. ...

A recent study on post-superplastic forming properties has shown that heating time prior to testing has a major effect on the post-forming properties of superplastically-formed AZ31 Magnesium alloy sheets. To this point, there has been very little examination into the effects of pre-heating or annealing on superplastic forming. In this work, these effects are examined using AZ31 Mg alloy sample...

This paper compares two types of polylactic acid (PLA) coating on AZ31 alloy obtained by dip and electrospinning. Both were loaded with gentamicin sulphate (GS) the drug-loading efficiency release assessed. A higher encapsulation GS was seen for (73% 49.53%, respectively) compared to nanofiber (65% 12.37%, respectively). Furthermore, antibacterial effect samples without assessed using Gram-nega...