The present study examined RTI-371 [3β-(4-methylphenyl)-2β-[3-(4-chlorophenyl)-isoxazol-5-yl]tropane], a phenyltropane cocaine analog with effects distinct from cocaine, and assessed potential mechanisms for those effects by comparison with its constitutional isomer, RTI-336 [3β-(4-chlorophenyl)-2β-[3-(4-methylphenyl)-isoxazol-5-yl]tropane]. In mice, RTI-371 was less effective than cocaine and ...

Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317 1. Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 319 1.1 Search Strategy . . . . . . . . . . ....

1.18.1 Beaconing 333 1.18.2 Route-Following 334 1.18.3 Path Integration 335 1.18.4 Map-Based Navigation 336 1.18.4.1 Small-Scale Maps (Centimeters to Meters) 336 1.18.4.2 Large-Scale Maps (Kilometers to Hundreds of Kilometers) 336 1.18.4.3 A Visual-Based Large-Scale Cognitive Map 337 1.18.4.4 A Sun-Calibrated Magnetic Compass 339 1.18.4.5 The Missing Links I – Navigation Behavior 340 1.18.4.5.1...

CONTENTS Introduction ........................................................ Nuclear arrangement in the teleneephalon .............................. The olfactory bulb ............................................... The accessory olfactory bulb ..................................... Nucleus olfactorius anterior ...................................... The nuclear groups in the ventromedial porti...

• The need to model rare events of univariate time series has led to many recent advances in theory and methods. In this paper, we review telegraphically the literature on extremes of dependent time series and list some remaining challenges. Key-Words: • Bayesian statistics; Box–Cox transformation; clustering; dependence; extremal index; extremogram; generalized extreme-value distribution; gene...

Plasmin not only functions as a key enzyme in the fibrinolytic system but also directly inactivates factor VIII and other clotting factors such as factor V. However, the mechanisms of plasmin-catalyzed factor VIII inactivation are poorly understood. In this study, levels of factor VIII activity increased approximately 2-fold within 3 min in the presence of plasmin, and subsequently decreased to...

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