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The protein tyrosine phosphatase Shp2 (PTPN11) is crucial for normal brain development and has been implicated in dorsal telencephalic neuronal and astroglia cell fate decisions. However, its roles in the ventral telencephalon and during oligodendrogenesis in the telencephalon remain largely unknown. Shp2 gain-of-function (GOF) mutations are observed in Noonan syndrome, a type of RASopathy asso...
In addition to genetic alterations, cancer cells are characterized by myriad epigenetic changes. EZH2 is a histone methyltransferase that is over-expressed and mutated in cancer. The EZH2 gain-of-function (GOF) mutations first identified in lymphomas have recently been reported in melanoma (~2%) but remain uncharacterized. We expressed multiple EZH2 GOF mutations in the A375 metastatic skin mel...
The tension-driven gating transition in the large mechanosensitive channel MscL proceeds through detectable states of intermediate conductance. Gain-of-function (GOF) mutants with polar or charged substitutions in the main hydrophobic gate display altered patterns of subconducting states, providing valuable information about gating intermediates. Here we present thermodynamic analysis of severa...
Herein, boronic acid is incorporated into a graphene oxide (GO) structure in order to synthesise a graphene organic framework (GOF) with enhanced electrochemical performance. The results obtained indicate that the GOF favours a 4e(-) reduction pathway in the oxygen reduction reaction (ORR).
Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.
هدف: پیشرفت جوامع بالاخص کشورهای درحال توسعه تا حد زیادی در گرو گسترش نهادهای دانشگاهی است. هم‌چنین یکی از مهم‌ترین ویژگی‌های آموزشی، درهم‌تنیدگی ساختارهای آموزش و اشتغال واقع هر آموزشی باید بازدهی یا توجیه اقتصادی داشته باشد که عالی‌ترین نوع آن ایجاد متناسب با فراگیر بر این اساس پژوهش حاضر به بررسی وضعیت راهیابی دانشجویان فارغ‌التحصیلان کارشناسی ارشد دکتری رشته تکنولوژی بازار کار عوامل مؤثر نظ...
The Design Patterns book introduced twenty-three patterns for object oriented software design. These patterns are used widely, but only in their intended domain of software design. We describe how six of these patterns can be used for the conceptual design of graphical user interfaces. By using these patterns, designers can produce interfaces which are more consistent, make good use of screen s...
1 Intent • Create families of related objects without specifying subclass names Applicability • When clients cannot anticipate groups of classes to instantiate Structure Abstract Factory GoF Object Creational Abstract Factory example in C++
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