Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammator...

Introduction The aim of this study was to discuss the effects and mechanisms lncRNA in renal injury induced by diabetes vivo vitro study. Material methods Collecting healthy DN patients, measuring ANRIL expression RT-qPCR assay serum. Measuring normal, 10d 20d model rats kidney. LDH, MDA, SOD, IL-6 TNF-α concentration Elisa assay, evaluating kidney pathology HE staining, cell apoptosis TUNEL re...

introduction: the inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (cox). cox catalyzes the formation of prostaglandins from arachidonic acid. among prostaglandins, 15-deoxy-d12, 14-prostaglandin j2 (15d-pgj2), an endogenous ligand of peroxisome proliferator-activated receptor-gamma (ppar-γ), has been demonstrated to have anti-inflam...

Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...

The main physiologic function of adipokines on the energy metabolism and cardiovascular homeostasis, among others, are well known. In last years, our laboratory is providing increasing evidence about possible role as mediators vascular damage, by inducing different pro-inflammatory pro-senescent mechanisms. secretion like visfatin or dipeptidylpeptidase-4 (DPP4) adipose tissue, particularly vis...

Purpose: To investigate the effect of phycocyanin on myocardial ischemia-reperfusion injury, and possible mechanisms involved.
 Methods: Twenty-four Sprague-Dawley (SD) rats were randomly divided into Sham group (only threading without ligation), IRI (myocardial injury group) (phycocyanin pretreatment + group). The heart was harvested cardiomyocytes isolated. Colorimetry used to determine ...

Purpose: To study the effect of dexmedetomidine (Dex) on myocardial ischemia-reperfusion injury (MIRI), and associated mechanism action.Methods: Sixty Sprague-Dawley (SD) rats were assigned to sham, (I/R), Dex, MD groups (methyllycaconitine prior injection with Dex), 15 in each group. Pathological changes tissues determined all groups. Protein expression levels HMGB1, TLR4, NF-κB myeloid differ...

Constitutive NF-E2-related factor 2 (Nrf2, NFE2L2) activation has been recently reported to play a pivotal role in enhancing cell survival and resistance to anticancer drugs in many tumors. Wogonin had strong reversal potency via reduction of Nrf2 mRNA in Adriamycin (ADR)-induced resistant human chronic myelogenous leukemia (CML) K562/A02, but the mechanism of reduction of Nrf2 mRNA was still u...

The superoxide-forming NADPH oxidase homologues, Nox1, Nox2, and Nox5, seem to mediate the pro-atherosclerotic vascular phenotype. The hydrogen peroxide-forming Nox4 afforded vascular protection, likely via NF-E2-related factor-2 (Nrf2) activation and/or Nox2 downregulation in transgenic mice. We hypothesized that oxidative stress in the intact vasculature involves, aside from the upregulation ...