Background: Acute kidney injury (AKI) is defined as a failure in renal function leading to insufficiency of fluid and electrolyte homeostasis. Thus, sensitive biomarkers of renal tubular injury are needed to detect AKI earlier. In this study, urinary beta 2-microglobulin (β2-MG) and urinary N-acetyl-β-D-glucosaminidase (NAG) were evaluated for AKI prognosis/diagnosis in pediatric patients suffe...

Dialytic clearance of p-cresyl sulfate (pCS) and other protein-bound toxins is limited by diffusive convective therapies, only a few studies have examined how to improve their removal adsorptive membranes. This study tested the hypothesis that high-flux polymethylmethacrylate (PMMA) dialysis membranes with capacity increase pCS compared polysulfone membranes, in postdilution on-line hemodiafilt...

Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how β2-microglobulin (β2-M) supports lethal metastasis in vivo in human prostate, breast, lung, and renal cancer cells. β2-M mediates this process by activating epithelial to mesenchymal transition (EMT) to promote lethal bone and soft tissue metastases in host mice. β2-M interacts w...

The plasma levels of cystatin C, β2-microglobulin, beta-trace protein, retinol binding protein (RBP) and creatinine were determined in plasma samples from 111 randomly selected patients with eGFRcystatin C ≤ 60% of eGFRcreatinine and from 55 control patients with 0.9eGFRcreatinine ≤ eGFRcystatin C ≤ 1.1eGFRcreatinine (eGFRcystatin C ≈ eGFRcreatinine). The concentration ratios of cystatin C/crea...

Background: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor worldwide. The main risk factors are tobacco in the form of chewing, smoking and alcohol consumption. The incidence is rated as one among the highest in the world and the use of tobacco in various forms is increasingly associated with the cause of OSCC. In oral cancer the study of tumor markers have been limited ...

OBJECTIVE The aim of this retrospective study was to evaluate the efficacy and prognostic factors of bortezomib and dexamethasone (BD) chemotherapy regimen in the treatment of newly diagnosed multiple myeloma (MM) patients in our hospital. METHODS A total of 47 newly diagnosed MM patients treated in our hospital from May 2010 to September 2016 were included in this study. All the enrolled pat...

A 69-year-old man presented with a few years’ history of nodules on the buttocks. Past history included chronic renal failure controlled with haemodialysis for 19 years and a decompression operation for carpal tunnel syndrome. Physical examination revealed a red-brown pediculated nodule 50×20 mm in diameter on the sacral region (Fig. 1A). In addition, 120×80 mm elastic, hard subcutaneous masses...

To date, there are 27 types of amyloidosis known extracellular fibril proteins in human, and each amyloidosis is characterized amyloid protein precursor, systemic (S) or localized organ (L), and syndrome or involved tissues [1]. In the nomenclature, dialysis-related amyloidosis (DRA) is defined as β2-microglobulin-related (Aβ2M) amyloid which precursor protein is β2microglobulin (β2-m). It is a...