background: recently, the development of new biomarkers as prognostic and predictive markers in prostate cancer has been crucial. objectives: this study was aimed to determine whether serum vascular endothelial growth factor (vegf) levels would be a prognostic marker or risk assessment factor in patients with prostate cancer and to investigate whether it could differentiate cancerous tissue fro...

Bifidobacterium longum subsp. longum CMCC P0001, a standard probiotic strain in China, has been widely used in clinical medicine for more than 20 years. Here we report the genome features of B. longum strain CMCC P0001.

Purpose: Angiogenesis plays an important role in a multitude of biological processes including those of tumorigenesis and cancer progression. Hypoxia is the prime driving factor for tumor angiogenesis and the family of hypoxiainducible factors (HIFs) plays a pivotal role in this process. The role of HIF in tumor angiogenesis has been underscored in different carcinomas but yet to be reported fo...

objective(s): herbal medicines are promising cancer preventive candidates. it has been shown that punica granatum l. could inhibit angiogenesis and tumor invasion. in this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (ppe) is partly attributable to peroxisome proliferator-activated receptors (ppars) activation in the human umbilical vein endothelial cell...

Exposure to exercise following a breast cancer diagnosis is associated with reductions in the risk of recurrence. However, it is not known whether breast cancers within the same molecular-intrinsic subtype respond differently to exercise. Syngeneic mouse models of claudin-low breast cancer (i.e., EO771, 4TO7, and C3(1)SV40Tag-p16-luc) were allocated to a uniform endurance exercise treatment dos...

background and objective: vascular endothelial growth factor (vegf) is a cytokine which is overexpressed in many malignant cancers including leukemia. vegf plays an important role in tumor invasion and metastasis. determination of the pattern of vegf expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

BACKGROUND Cell-based angiogenesis is a promising treatment for ischemic diseases; however, survival of implanted cells is impaired by the ischemic microenvironment. In this study, mesenchymal stem cells (MSCs) for cell transplantation were preconditioned with trimetazidine (TMZ). We hypothesized that TMZ enhances the survival rate of MSCs under hypoxic stimuli through up-regulation of HIF1-α. ...

this study investigates the effects of melatonin on the sperm quality and testis weight after the combination of swimming exercise and nandrolone decanoate (deca). two groups of male wistar rats were treated for eight weeks as follows; group a consist of co (control), sham, n (deca), s (swimming) and ns (deca plus swimming); and group b: sham m (sham melatonin), m (melatonin), mn (melatonin plu...

Objective. Hydroalcoholic extract of leaves of Mallotus oppositifolius (MOE), a plant used for CNS conditions in Ghana, was investigated for acute antidepressant effects in the forced swimming (FST) and tail suspension tests (TST). Results. In both FST and TST, MOE (10, 30, and 100 mg kg(-1)) significantly decreased immobility periods and frequencies. A 3-day pretreatment with 200 mg kg(-1), i....

objective(s): abdominal adhesions are one of the most important problems, occurring after intra-abdominal surgery in more than 90% of cases. this condition is the leading cause of bowel obstruction, infertility, and abdominal/pelvic pain. gold nanoparticles (gnps) have been shown to be non-toxic and exhibit anti-inflammatory, anti-angiogenic and antioxidant activities. the purpose of this study...