BACKGROUND AND PURPOSE Zonisamide (ZNS) is a useful antiepileptic drug with a broad therapeutic spectrum. However, there is limited information on the long-term use of ZNS as a monotherapy. This study investigated the long-term effects of ZNS as a monotherapy for the treatment of epilepsy. METHODS We retrospectively analyzed the records of epilepsy patients treated with ZNS monotherapy at our...

The discovery of zonisamide (ZNS) did not result from a search for new antiepileptic drug (AED). A continuous random screening for anticonvulsant activity had been in progress for many years at the research laboratories of Dainippon Pharmaceutical Co., Ltd. ZNS was discovered by serendipity in 1974 during routine testing of 1,2-benzisoxazole derivatives which were synthesized for the management...

The core-shell structural Fe3O4/ZnS nanocomposites with controllable shell thickness were well-fabricated via seed-mediate growth method. Structural and morphological characterizations reveal the direct deposition of crystalline II-VI compound semiconductor ZnS shell layer on Fe3O4 particles. Spin dependent electrical transport is studied on Fe3O4/ZnS nanocomposites with different shell thickne...

Wurtzite-structured materials, such as ZnO, ZnS, GaN, and AlN, have an important characteristic: the presence of polar surfaces that result from cationor anion-terminated atomic planes. Consequently, a series of novel nanostructures, such as nanosprings, nanorings, nanohelices, and nanobows, have been formed. The mechanism that drives the formation of these novel configurations minimizes the el...

Cetyltrimethyl ammonium bromide cationic (CTAB) surfactant was used as template for the synthesis of nanoclusters of ZnS composed of nanowires, by hydrothermal method. The structural and morphological studies were performed by using X-ray diffraction (XRD), scanning electron microscopy (SEM) and high resolution transmission electron microscopy (HRTEM) techniques. The synthesized ZnS nanocluster...

Pure and doped ZnS nanocrystalline phosphors were prepared at room temperature using a chemical synthesis method. Transmission electron microscopy observation shows that the size of the ZnS crystals is in the 2-3 nm range and SAED pattern confirms the cubic and crystalline nature of the observed samples, which are in agreement with X-Ray analysis. Interesting luminescence characteristics such a...

Mn-doped ZnS nanorods synthesized by solvothermal method were successfully coated with ZnS shells of various thicknesses. The powder X-ray diffraction (XRD) measurements showed the ZnS:Mn nanorods were wurtzite structure with preferential orientation along c-axis. Transmission electron microscopy images (TEM) revealed that the ZnS shells formed from small particles, growing along a-axis orienta...

Heterostructures involving ZnS/GaN show promise for the injection of holes from p-GaN into n-ZnS. Utilizing knowledge obtained from ZnS phosphor technology, this combination could result in a new type of multi-color electroluminescent display. Further, this combination provides a very interesting interface. Both ZnS and GaN are very ionic materials. Hence, it is desirable that the interface wil...

OBJECTIVE To investigate the effects of topiramate (TPM), zonisamide (ZNS), and levetiracetam (LEV) on cognitive network activations in patients with focal epilepsy using an fMRI language task. METHODS In a retrospective, cross-sectional study, we identified patients from our clinical database of verbal fluency fMRI studies who were treated with either TPM (n = 32) or ZNS (n = 51). We matched...

Zinc Sulfide (ZnS) thin films were deposited on glass substrates at the pressure of 10-6 mbar by thermal resistor evaporation technique. The effects of annealing on the structural, optical properties of ZnS films were studied. Crystalline ZnS films have been analyzed by X-ray diffraction. Only cubic phase with the preferred (111) plane was found in ZnS films. Optical characteristics were studie...