Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum and ZAG mRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated the effects of ZAG administration on the body weight, body fat and glucose met...

OBJECTIVE To investigate the levels of zinc-α-2-glycoprotein (ZAG) among Omani AIDS patients receiving combined antiretroviral therapy (cART). METHODS A total of 80 Omani AIDS patients (45 males and 35 females), average age of 36 years, who were receiving cART at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, were tested for the levels of ZAG. In addition, 80 healthy blood donors...

Neurons acquire distinct cell identities and implement differential gene programs to generate their appropriate neuronal attributes. On the basis of position, axonal structure and synaptic connectivity, the 302 neurons of the nematode Ceanorhabditis elegans are divided into 118 classes. The development and differentiation of many neurons require the gene zag-1, which encodes a deltaEF1/ZFH-1 Zn...

Objective. To investigate the changes of serum zinc-α2-glycoprotein (ZAG) in type 2 diabetes mellitus (T2DM) with eGFR mild decrease. Subjects and Methods. A total of 438 T2DM patients (61.3 ± 4.0 y) were recruited and the demographic, anthropometric, and biochemical parameters were all collected. Serum ZAG levels were determined by commercially available ELISA kits. Results. The proportion of ...

CONTEXT Zinc-α2-Glycoprotein (ZAG) is an adipokine with lipolytic action and is positively associated with adiponectin in adipose tissue. We hypothesize that ZAG may be related with hydrocarbonate metabolism disturbances observed in gestational diabetes mellitus (GDM). OBJECTIVE The aim of this study was to analyze serum ZAG concentration and its relationship with carbohydrate metabolism in p...

Today we examine the zig-zag product introduced by Reingold, Vadhan, and Wigder­ son [2] and Capalbo, Reingold, Vadhan, and Wigderson [1]. The product leads to a remarkable constructioon of expander graphs needed in the Spiser-Spielman code. In addition, their works introduce a probabilistic viewpoint of expansion. In previous liter­ ature, the spectral techniques are used to analyze the expans...

We consider the standard semi-direct product AoB of finite groups A,B. We show that with certain choices of generators for these three groups, the Cayley graph of A o B is (essentially) the zigzag product of the Cayley graphs of A and B. Thus, using the results of [RVW00], the new Cayley graph is an expander if and only if its two components are. We develop some general ways of using this const...

Today we examine the zig-zag product introduced by Reingold, Vadhan, and Wigderson [2] and Capalbo, Reingold, Vadhan, and Wigderson [1]. The product leads to a remarkable constructioon of expander graphs needed in the Spiser-Spielman code. In addition, their works introduce a probabilistic viewpoint of expansion. In previous literature, the spectral techniques are used to analyze the expansion ...

AIMS/INTRODUCTION Zinc-α2-glycoprotein (ZAG) is associated with the loss of adipose tissue in cancer cachexia, and has recently been proposed to be a candidate factor in the regulation of bodyweight. The aim of the study was to investigate the effects of ZAG on the proliferation and differentiation of 3T3-L1 preadipocytes. MATERIALS AND METHODS 3-(4,5-Dimethylthiazol-2-yl) 2,5-diphenyl tetraz...

Background: Zn2 glycoprotein (ZAG) is a relatively abundant glycoprotein that has potential as a biomarker for prostate cancer. We present a high-flow liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for measuring serum ZAG concentrations by proteolytic cleavage of the protein and quantification of a unique peptide. Methods: We selected the ZAG tryptic peptide EIPAWVPEDPAAQITK a...