نتایج جستجو برای: xdr
تعداد نتایج: 1279 فیلتر نتایج به سال:
Extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) has been reported to the WHO by 100 countries, including Colombia. An estimated 9.0% of people with multidrug-resistant TB have XDR-TB. We report the genome sequence of a Beijing XDR-TB clinical isolate from Buenaventura, Colombia. The genome sequence is composed of 4,298,162 bp with 4,359 genes.
BACKGROUND Extensively Drug-Resistant (XDR) Tuberculosis (TB) has posed a great threat to global health and finance systems, especially for developing countries with high TB and Multidrug-Resistant (MDR) TB burden. METHODS We retrospectively analyzed HIV-uninfected TB case confirmed and treated in Shandong Provincial Chest Hospital (SPCH) between January 2008 and December 2015. Unique charact...
The worldwide emergence of extensively drug-resistant tuberculosis (XDR TB) and a provisional definition for this form of TB were first reported in November 2005. A more detailed description of these findings and preliminary data from the U.S. National TB Surveillance System (NTSS) were published in 2006. The U.S. data indicated that 74 TB cases reported during 1993-2004 met the case definition...
زمینه و اهداف: انسان خود باعث پیدایش سل مقاوم به دارو شده است. پیدایش جهانی xdr-tb نخستین بار در سال 2005 میلادی گزارش شد. xdr-tb فرمی از مقاومت دارویی است که در آن باسیل سل علاوه بر انکه حداقل به 2 داروی مهم و اصلی ضد سل (ایزونیازید و ریفامپین) مقاوم است. به یک فلوروکوئینولون و حداقل به سه داروی تزریقی امیاکسین،کانامایسین و کاپرئومایسین مقاوم است. با توجه به اینکه میزان xdr-tb به سرعت رو به گس...
BACKGROUND South Africa has a large burden of extensively drug-resistant tuberculosis (XDR-TB); only 15% of XDR-TB patients have successful outcomes. OBJECTIVE To describe the safety and effectiveness of bedaquiline (BDQ) in the South African BDQ Clinical Access Programme. DESIGN An interim cohort analysis. RESULTS Of the first 91 patients enrolled between March 2013 and July 2014 (with f...
BACKGROUND Extensively drug-resistant (XDR) tuberculosis (TB) is a major public health threat in South Korea. METHODS We analyzed baseline epidemiological data for 250 patients enrolled in an ongoing prospective observational study of TB at a large tertiary referral hospital in South Korea. RESULTS Twenty-six subjects with XDR TB were identified; all were patients who had previously receive...
The article by Andrews et al. demonstrating exogenous reinfection as a cause of multidrug-resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB) in South Africa in the current issue of the Journal brings chilling news [1]. The authors report that all of the MDR and XDR TB that occurred in patients previously treated for TB was the result of primary transmission, rather than emer...
To estimate the prevalence of extensively drug-resistant tuberculosis (XDR TB) in China, we retrospectively analyzed drug-resistance profiles of 989 clinical Mycobacterium tuberculosis isolates. We found 319 (32.3%) isolates resistant to ≥1 first-line drugs; 107 (10.8%) isolates were multidrug resistant, of which 20 (18.7%) were XDR. XDR TB is of major concern in China.
BACKGROUND Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) have emerged in high-HIV-prevalence settings, which generally lack laboratory infrastructure for diagnosing TB drug resistance. Even where available, inherent delays with current drug-susceptibility testing (DST) methods result in clinical deterioration and ongoing transmission of MDR and XDR-TB. Identif...
OBJECTIVES Extensively drug-resistant tuberculosis (XDR-TB) is more expensive and difficult to treat than multidrug-resistant tuberculosis (MDR-TB), and outcomes for patients are much worse; therefore, it is important that clinicians understand the magnitude and distribution of XDR-TB. We conducted a retrospective study to compare the estimated incidence of and risk factors for M/XDR-TB with th...
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