YES-associated protein 2 (YAP2) transcriptional regulator drives a multitude of cellular processes, including the newly discovered Hippo tumor suppressor pathway, by virtue of the ability of its WW domains to bind and recruit PPXY-containing ligands to specific subcellular compartments. Herein, we employ an array of biophysical tools to investigate allosteric communication between the WW tandem...

We present recent diboson production measurements from the D0 experiment at Fermilab’s Tevatron collider. The production of ZZ was observed using leptonic final states. Zγ → ννγ was observed and used to set the most stringent limits from a hadron collider on anomalous Zγγ and ZZγ trilinear gauge couplings (TGCs). WW events with leptonic final states and WW +WZ events with semi-leptonic final st...

PAGE INTRODUCTION ................................................................ 395 Materials, methods and remarks. ............................................... Crosses between YW and YY ................................................ Crosses between YW and WW ............................................... Crosses between YY and WW ............................................... Silk gl...

The unprecedented increase in litter size over the last decade has led to a perceived increase in the number of fallback pigs (Sus scrofa). However, there is little peer-reviewed data available regarding the biological differences between fallback pigs and their normal cohorts. Therefore, the objective of this experiment was to identify differences in the biology and physiology, and thus the gr...

Records (2,910) of birth (BWT), weaning (WW), and yearling weight (YW) of F1 calves produced in a top-cross experiment involving Angus, Hereford, Pooled Hereford, Charolais, Limousin, Simmental, Gelbvieh, Maine-Anjou, Chianina, Tarentaise, Shorthorn, and Salers bulls mated to Hereford and Angus cows and records (4,592) of WW on three-breed-cross calves out of 986 F1 females of the same breed cr...

The human transcription elongation factor CA150 contains three N-terminal WW domains and six consecutive FF domains. WW and FF domains, versatile modules that mediate protein-protein interactions, are found in nuclear proteins involved in transcription and splicing. CA150 interacts with the splicing factor SF1 and with the phosphorylated C-terminal repeat domain (CTD) of RNA polymerase II (RNAP...

WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs (PRM) and phosphorylated serine/threonine-proline sites. WW domains are found in many different structural and signaling proteins that are involved in a variety of cellular processes, including RNA transcription and processing, protein trafficking and stability, receptor s...

OBJECTIVE To describe prostate cancer treatment decision making, focusing on knowledge and attitudes toward observation, known as watchful waiting (WW) or active surveillance (AS), and reasons for not choosing WW/AS. METHODS Semistructured in-person interviews were conducted with 21 men (14 black; 7 white) with recently diagnosed localized prostate cancer. RESULTS All cancers were detected ...