One of the promising methods to improve yeast fermentation performance in high gravity brewing is to increase pitching rate in the bioreactor. In this study, fermentation with four different pitching rates (1.5×107, 4.5×107, 7.5×107, and 10.5×107 viable cells/ml wort) was carried out to investigate the impact of pitching rate on yeast fermentation performance and beer quality from 24oBx wort. T...

Commercially available St. John's wort (Hypericum perforatum) preparations and some of their main constituents (hypericin, pseudohypericin, hyperforin, rutin, and quercetin) were examined for their potential to inhibit carcinogen activation by human cytochrome P450 1A1 (CYP1A1). We used a reconstituted system consisting of purified human CYP1A1, purified human NADPH-cytochrome P450 reductase, a...

OBJECTIVE To examine the association between access to conventional health care and the use of St. John's wort among adults who report depressive symptoms. STUDY DESIGN Logistic secondary analysis of the Complementary and Alternative Medicine Supplement to the 2002 National Health Interview Survey (NHIS). STUDY POPULATION Adults who report depressive symptoms and used St. John's wort (n = 2...

Herbs, vitamins, and other dietary supplements may augment or antagonize the actions of prescription and nonprescription drugs. St. John's wort is the supplement that has the most documented interactions with drugs. As with many drug-drug interactions, the information for many dietary supplements is deficient and sometimes supported only by case reports. Deleterious effects are most pronounced ...

This paper deals with the effect of Tween 80 and ergosterol supplementation to the 24oPt wort with 30% maltose syrup adjunct on the fermentation performance of the immobilized yeast in calcium alginate gel. The higher the content of supplements in the wort, the higher the yeast growth, the sugar and free amino nitrogen consumption rates and the ethanol production rate but the lower the ethanol ...

Extracts of Hypericum perforatum L. (St John’s wort) are now successfully Abstract competing for status as a standard antidepressant therapy. Because of this, great effort has been devoted to identifying the active antidepressant compounds in the extract. From a phytochemical point of view, St John’s wort is one of the best-investigated medicinal plants. A series of bioactive compounds has been...

: In very high gravity brewing, fed-batch fermentation was carried out with Saccharomyces cerevisiae immobilized in calcium alginate gel. The specific gravity of initial wort and feeding medium originated from 55% malt and 45% maltose syrup adjunct was adjusted to 28oBrix and 41oBx, respectively. The effect of supplementation of mixture of Tween 80 and ergosterol to the initial wort or to the f...

St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we show that hyperforin, a constituent of St. John's wort with antidepressant activity, is a potent ligand ...