Michael Trott∗ Wolfram Research, Inc., 100 Trade Center Drive, Champaign Illinois 61820-7237 (Dated: March 18, 2005) Abstract This paper o ers a demonstration of the appearance and general document features of the Physical Review style sheet as adapted from the American Physical Society speci cations for journal submissions. Although the topics in this paper were written speci cally for Publico...

OBJECTIVE To describe the diabetes phenotype in Wolfram syndrome compared with type 1 diabetes, to investigate the effect of glycemic control on the neurodegenerative process, and to assess the genotype-phenotype correlation. RESEARCH DESIGN AND METHODS The clinical data of 50 patients with Wolfram syndrome-related diabetes (WSD) were reviewed and compared with the data of 24,164 patients wit...

Wolfram syndrome is a progressive neurodegenerative disorder transmitted in an autosomal recessive mode. We report two Wolfram syndrome families harboring multiple deletions of mitochondrial DNA. The deletions reached percentages as high as 85-90% in affected tissues such as the central nervous system of one patient, while in other tissues from the same patient and from other members of the fam...

OBJECTIVE Wolfram syndrome is an autosomal recessive neurodegenerative disorder characterized by diabetes insipidus, diabetes (nonautoimmune), optic atrophy, and deafness (a set of conditions referred to as DIDMOAD). The WFS1 gene is located on the short arm of chromosome 4. Wolfram syndrome prevalence is 1 in 770,000 live births, with a 1 in 354 carrier frequency. RESEARCH DESIGN AND METHODS...

In the qualitative classiication of cellular automata (CA) rules by Wolfram, there exists a class of CA rules (called Class 4) which exhibit complex pattern formation and long-lived dynamical activity (long transients). These properties of Class 4 CA's has led to the conjecture that Class 4 rules are Universal Turing machines i.e. they are bases for computational universality. We describe an em...

Wolfram syndrome is an autosomal recessive disorder characterized by juvenile diabetes mellitus, diabetes insipidus, optic atrophy and a number of neurological symptoms including deafness, ataxia and peripheral neuropathy. Mitochondrial DNA deletions have been described in a few patients and a locus has been mapped to 4p16 by linkage analysis. Susceptibility to psychiatric illness is reported t...

We have constructed a CAI system incorporated with Mathematica for science and engineering students. The advantages of this system are that (1) we can use variables in mathematical formulas so that different problems can be shown to the users, (2) we can use algebraic formulas, (3) the answer is automatically made by Mathematica using the given process to the answer, (4) various expressions of ...