نتایج جستجو برای: wnt signalling and hek293t cells

تعداد نتایج: 17086001  

2017
Laura Mariotti Katie Pollock Sebastian Guettler

The Wnt/β-catenin signalling pathway is pivotal for stem cell function and the control of cellular differentiation, both during embryonic development and tissue homeostasis in adults. Its activity is carefully controlled through the concerted interactions of concentration-limited pathway components and a wide range of post-translational modifications, including phosphorylation, ubiquitylation, ...

Journal: :The EMBO journal 2012
Satoshi Ota Shizuka Ishitani Nobuyuki Shimizu Kunihiro Matsumoto Motoyuki Itoh Tohru Ishitani

Nemo-like kinase (NLK/Nlk) is an evolutionarily conserved protein kinase involved in Wnt/β-catenin signalling. However, the roles of NLK in Wnt/β-catenin signalling in vertebrates remain unclear. Here, we show that inhibition of Nlk2 function in zebrafish results in decreased Lymphoid enhancer factor-1 (Lef1)-mediated gene expression and cell proliferation in the presumptive midbrain, resulting...

2013
Jesús Cosín-Roger Dolores Ortiz-Masiá Sara Calatayud Carlos Hernández Angeles Álvarez Joaquin Hinojosa Juan V. Esplugues Maria D. Barrachina

Macrophages, which exhibit great plasticity, are important components of the inflamed tissue and constitute an essential element of regenerative responses. Epithelial Wnt signalling is involved in mechanisms of proliferation and differentiation and expression of Wnt ligands by macrophages has been reported. We aim to determine whether the macrophage phenotype determines the expression of Wnt li...

Journal: :International Journal of Surgery 2010

Journal: :The International journal of developmental biology 2002
Vicki L Church Philippa Francis-West

Wnts control a number of processes during limb development--from initiating outgrowth and controlling patterning, to regulating cell differentiation in a number of tissues. Interactions of Wnt signalling pathway components with those of other signalling pathways have revealed new mechanisms of modulating Wnt signalling, which may explain how different responses to Wnt signalling are elicited in...

Journal: :The EMBO journal 2012
Christof Niehrs Sergio P Acebron

Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell prolife...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Kah Yee Goh Natalie Weili Ng Thilo Hagen Takao Inoue

Wnt signaling is mediated by three classes of receptors, Frizzled, Ryk, and Ror. In Caenorhabditis elegans, Wnt signaling regulates the anterior/posterior polarity of the P7.p vulval lineage, and mutations in lin-17/Frizzled cause loss or reversal of P7.p lineage polarity. We found that pak-1/Pak (p21-activated kinase), along with putative activators of Pak, nck-1/Nck, and ced-10/Rac, regulates...

2016
David J. Duffy Aleksandar Krstic Thomas Schwarzl Melinda Halasz Kristiina Iljin Dirk Fey Bridget Haley Jenny Whilde Saija Haapa-Paananen Vidal Fey Matthias Fischer Frank Westermann Kai-Oliver Henrich Steffen Bannert Desmond G. Higgins Walter Kolch

Wnt signalling is involved in the formation, metastasis and relapse of a wide array of cancers. However, there is ongoing debate as to whether activation or inhibition of the pathway holds the most promise as a therapeutic treatment for cancer, with conflicting evidence from a variety of tumour types. We show that Wnt/β-catenin signalling is a bi-directional vulnerability of neuroblastoma, mali...

2014
Maria Gagliardi Ana Hernandez Ian J. McGough Jean-Paul Vincent

A key step in the canonical Wnt signalling pathway is the inhibition of GSK3β, which results in the accumulation of nuclear β-catenin (also known as CTNNB1), and hence regulation of target genes. Evidence suggests that endocytosis is required for signalling, yet its role and the molecular understanding remains unclear. A recent and controversial model suggests that endocytosis contributes to Wn...

Journal: :Cardiovascular research 2017
Alexia Hulin Vicky Moore Jeanne M James Katherine E Yutzey

AIMS Myxomatous valve disease (MVD) is the most common aetiology of primary mitral regurgitation. Recent studies suggest that defects in heart valve development can lead to heart valve disease in adults. Wnt/β-catenin signalling is active during heart valve development and has been reported in human MVD. The consequences of increased Wnt/β-catenin signalling due to Axin2 deficiency in postnatal...

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