نتایج جستجو برای: wnt pathway
تعداد نتایج: 325509 فیلتر نتایج به سال:
Wnt signaling affects both bone modeling, which occurs during development, and bone remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially known to affect the differentiation of osteoblasts. In this review, we summarize recent advances in understanding the mechanisms of Wnt signaling, which is divided into two major branches: the canonical pathway and the n...
Abnormal inactivation of the Wnt/β-catenin signaling pathway is involved in skin diseases like androgenetic alopecia, vitiligo and canities, but small-molecule activators are rarely described. In this study, we investigated stimulatory effects escin on canonical cultured human dermal papilla cells (hDPCs). Escin stimulated signaling, resulting increased β-catenin lymphoid enhancer-binding facto...
The Wnt signaling pathway plays an important role not only in embryonic development but also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt signaling has been shown as an important regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. Induction of the Wnt signaling pathway promotes bone formation while inactivation of the path...
WNT signaling pathway is implicated in carcinogenesis, embryogenesis and organogenesis [4]. WNTs are a family of secreted-type glycoproteins with 22∼24 conserved cysteine residues. WNT signals are transduced through seven-transmembrane-type WNT receptors encoded by Frizzled (FZD) genes to the β-catenin TCF pathway, the JNK pathway, or the Ca2+-releasing pathway. Gain-of-function mutations of po...
BACKGROUND The Wnt pathway mediates differentiation of epithelial tissues; depending on the tissue types, Wnt can either drive or inhibit the differentiation process. We hypothesized that key genes in the Wnt pathway are suppressed in the human airway epithelium under the stress of cigarette smoking, a stress associated with dysregulation of the epithelial differentiated state. METHODOLOGY/PR...
This article refers to:RETRACTED ARTICLE: A new mixed-ligand Co(II)-phosphonate framework: inhibited the wnt signaling pathway and exerted promotion activity on fracture rehabilitation
Background: Differentiating oligodendrocyte precursor cells (OPCs) into oligodendrocytes could be improved by inhibiting signaling pathways such as Wnt and Notch. 9-cis-retinoic acid (9-cis-RA) and 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) can ameliorate oligodendrogenesis. We investigated whether they could increase oligodendrogenesis by inhibiting the Wnt and Notch signaling pathways.Methods: Co...
Wnt/β-catenin (WβC) signaling pathway is an important for the maintenance of cellular homeostasis from embryonic developmental stages to adulthood. The canonical WβC essential neurogenesis, cell proliferation, and whereas noncanonical (WNT/Ca2+ WNT/PCP) responsible polarity, calcium maintenance, migration. Abnormal regulation involved in pathogenesis several neurodegenerative diseases such as A...
The Wnt pathway effector gene TCF7L2 has been linked to type II diabetes, making it important to study the role of Wnt signaling in diabetes pathogenesis. We examined the expression of multiple Wnt pathway components in pancreases from normal individuals and type II diabetic individuals. Multiple members of the Wnt signaling pathway, including TCF7L2, Wnt2b, beta-catenin, pGSK3beta, TCF3, cycli...
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