By Zak Rose-Reneau, Rachel Terry & 2 more. Endometrial Receptivity Testing and Subsequent Adjustment to Window of Implantation Timing Improve Pregnancy Success Rates Women Undergoing Assisted Reproductive Technology

Introduction: Cochlear implantation (CI) is now regarded as a standard treatment for children with severe to profound sensor neural hearing loss. This study aimed to compare the efficacy of the round window approach (RWA) and standard cochleostomy approach (SCA) in the preservation of residual hearing after CI in pediatric patients. Materials and Methods: This double-blind ran...

Background: Implantation is characterized by the interaction of two immunologically and genetically distinct tissues. The embryo differs from the cells of the mother, and would be rejected as a parasite by the immune system of the mother if it didn’t secrete immunosuppressive agents. Thus, immunological rejection of the fetus due to recognition of paternal antigens by the maternal immune system...

BACKGROUND Identification of new markers assessing endometrial receptivity may help in improving the clinical outcome of IVF. This study aimed at identifying genes expressed in human endometrium during the implantation window that could be used as such markers. METHODS A series of normoresponder patients (n = 31) underwent endometrial biopsies (n = 62, 2 per patient) during the early secretor...

background: it has been hypothesized that blastocyst integrin expression changes can affect the spontaneous miscarriage in polycystic ovarian syndromes (pcos). objective: in this study, the profile of integrin genes and proteins was investigated on blastocyst of the pcos experimental mouse model. materials and methods: 30 nmri female mice were equally divided into 3 groups: control, experimenta...

Objective(s): NOTCH signaling pathway is well known for its role in cell fate, cell survival, cell differentiation, and apoptosis. Some of the NOTCH signaling genes are critical for endometrial function and implantation in animals and appear to play a similar role in humans. The purpose of the current study was to investigate the potential roles of some main components of the NOTCH family in hu...

Background: Several studies indicate clear relationship between infertility and endometriosis. However, the etiology of this association is uncertain. Endometrial dysfunction is a possible cause of infertility in women with endometriosis, which could explain the high rates of implantation failure and miscarriages in these women. Delay in endometrial maturation and intrauterine biochemical abnor...

Background: Recent attention has focused on the expression of integrin molecules within the endometrium, and their relation to infertility. Objective: The present prospective study was undertaken to determine whether the endometrium of women with unexplained infertility differs in the expression of very late activation antigens (VLA) from the endometrium of normal fertile women. Methods: Thirty...

background: women with polycystic ovary syndrome have lower pregnancy rates, possibly due to the decreased uterine  receptivity.successful implantation depends on protein networks that are essential for cross-talk between the embryo and endometrium.apolipoprotein a1 has been proposed as a putative anti-implantation factor. in this study, we evaluated apolipoprotein a1 expression in human endome...