نتایج جستجو برای: wilms tumor gene 1
تعداد نتایج: 3825016 فیلتر نتایج به سال:
Mutations of the p53 tumor suppressor gene occur frequently in a variety of adult-onset tumors, including colon, breast, lung, and brain, yet are infrequently identified in pediatric malignancies. Wilms' tumor, a common solid tumor of childhood, can be associated with mutations of the WT1 gene. Alterations of the p53 gene have been shown to modulate the ability of WT1 to transactivate its targe...
We have examined the pattern of expression of the human PAX2 gene in Wilms' tumors and human fetal kidney by Northern blot and in situ hybridization. Human PAX2 encodes a paired box-containing protein and has a high degree of homology with mouse and Drosophila paired box genes. In situ hybridization analysis reveals that PAX2 is expressed in nephrogenic structures in fetal kidney and also in Wi...
Purpose: Wilms' tumor is a childhood cancer of the kidney with an incidence of ∼1 in 10,000. Cooccurrence of Wilms' tumor with 2q37 deletion syndrome, an uncommon constitutional chromosome abnormality, has been reported previously in three children. Given these are independently rare clinical entities, we hypothesized that 2q37 harbors a tumor suppressor gene important in Wilms' tumor pathogene...
Genetic alterations in tumor suppressor genes are believed to play an important role in the initiation of childhood and adult malignancies. Tumor-specific loss of heterozygosity for particular chromosomal regions has provided the starting point for the cloning of different tumor suppressor genes, including the Wilms tumor predisposing gene, WT1, at chromosome 11p13. This article reviews the pat...
1. Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, et al. Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies. Pediatrics 2015;136:e203‐14. 2. Hanson J, Gorman J, Reese J, Frazier G. Regulation of vascular endothelial growth factor, VEGF, gene promoter by the tumor suppressor, WT1. Front Biosci 2007;12:2279‐90. 3. ...
background: wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival. methods: in the current study, we analyzed her2/neu expression in 40 wilms' tumors. the clinico-demographic data of 40 patients with wilms' tumor were retrieved. immunohistochemical staining for her2/neu ...
wilms’ tumor is the most common abdominal tumor of childhood, and its cerebral metastasis is apparently very rare. the authors report an 18-month-old girl with wilms’ tumor and brain metastasis.
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