In contrast to the multitude of investigations regarding aesthetic changes in nasal surgery, few data are available concerning nasal function. This is especially important for cleft patients with a compromised nasal respiration.In this prospective study, 68 cleft patients, who underwent nasal surgery, were evaluated concerning aesthetic and respiratory outcome. To assess nasal respiration, acti...

INTRODUCTION Among patients with acute myeloid leukemia (AML), the DACO-016 randomized study showed reduction in mortality for decitabine [Dacogen(®) (DAC), Eisai Inc., Woodcliff Lake, NJ, USA] compared with treatment choice (TC): at primary analysis the hazard ratio (HR) was 0.85 (95% confidence interval 0.69-1.04; stratified log-rank P = 0.108). With two interim analyses, two-sided alpha was ...

PURPOSE To evaluate the efficacy of a combined macular buckle under direct vision and 23-gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling in refractory macular hole retinal detachment (MHRD) with extreme high axial myopia. DESIGN Prospective, randomised controlled study. PARTICIPANTS The study included 98 eyes of 98 patients of MHRD with extreme high axial (>3...

OBJECTIVE To determine the perceptions of general practitioners (GPs) about the benefits of coronary artery bypass surgery, in terms of gains in life expectancy, for different groups of patients. DESIGN A questionnaire survey of all GPs in Northern Ireland. SETTING A survey conducted collaboratively by the departments of public health medicine in each of the four health boards in the provin...

We propose an exact nonparametric inference scheme for the detection of nonlinearity. The essential fact utilized in our scheme is that, for a linear stochastic process with jointly symmetric innovations, its ordinary least square (OLS) linear prediction error is symmetric about zero. Based on this viewpoint, a class of linear signed rank statistics, e.g. the Wilcoxon signed rank statistic, can...

PURPOSE To compare the accuracy of estimating prostatic volume with digital rectal examination (DRE) by urological staffs with different experiences. Measurement of prostatic volume with transrectal ultrasonography (TRUS) serves as the reference standard. MATERIALS AND METHODS Thirty-nine consecutive male patients admitted with acute urinary retention had their prostatic volume estimated with...

PURPOSE To compare the anterior lens capsulotomy edge tear strength created by manual continuous curvilinear capsulorhexis (CCC), femtosecond laser capsulotomy (FSLC), and a new automated precision pulse capsulotomy (PPC) device. DESIGN A 3-arm study in paired human cadaver eyes. PARTICIPANTS A total of 44 eye specimens from 22 donors in the United States. METHODS Capsulotomy was performe...

In this paper, we consider applying the Wilcoxon’s idea for the construction of the one-sample problem to the two-sample case. For this, we show that the location translation parameter becomes a median of the distribution of the difference of two independent random variables under the location translation model. Based on this fact, we construct generalized signed-rank statistics for the two sam...

The Wilcoxon signed rank test is a frequently used nonparametric test for paired data (e.g., consisting of pre- and posttreatment measurements) based on independent units of analysis. This test cannot be used for paired comparisons arising from clustered data (e.g., if paired comparisons are available for each of two eyes of an individual). To incorporate clustering, a generalization of the ran...