The prediction of the location of disulfide bridges helps towards the solution of protein folding problem. Most of previous works on disulfide connectivity pattern prediction use the prior knowledge of the bonding state of cysteines. In this study an effective method is proposed to predict disulfide connectivity pattern without the prior knowledge of cysteins’bonding state. In previous research...

Neuroimaging studies have demonstrated that patients with Alzheimer's disease presented disconnection syndrome. However, little is known about the alterations of interhemispheric functional interactions and underlying structural connectivity in the AD patients. In this study, we combined resting-state functional MRI and diffusion tensor imaging (DTI) to investigate interhemispheric functional a...

Processing of motion and pattern has been extensively studied in the visual domain, but much less in the somatosensory system. Here, we used ultra-high-field functional magnetic resonance imaging (fMRI) at 7 Tesla to investigate the neuronal correlates of tactile motion and pattern processing in humans under tightly controlled stimulation conditions. Different types of dynamic stimuli created t...

We developed a computer model to simulate associative memory recall of patients with chronic schizophrenia. Model inputs consisted of words derived from normative data that differed in terms of connectivity and network size, with the former quantitatively represented by parametric weights and the latter by the specific number of word associates that formed a particular network. Previous behavio...

A sparsely connected associative memory model is tested with different pattern sets, and it is found that pattern recall is highly dependent on the type of patterns used. Performance is also found to depend critically on the connection strategy used to build the networks. Comparisons of topology reveal that connectivity matrices based on Gaussian distributions perform well for all pattern types...

Human organ, as the basic structural and functional unit in human body, is made of a large community of different cell types that organically bound together. Each organ usually exerts highly specified physiological function; while several related organs work smartly together to perform complicated body functions. In this study, we present a computational effort to understand the roles of genes ...

Measures of network structural integrity useful in the analysis and synthesis of power systems are discussed. Signal flow methodology is applied to derive an expression for the paths between sources and sinks in a power network. Connectivity and reach ability properties of the network are obtained using the minors of a modified connectivity matrix. Node-connectivity, branch connectivity and mix...