KRN633 is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. However, it is poorly water-soluble; consequently, relatively high doses are required to achieve substantial in vivo tumor growth suppression after oral administration. We subjected KRN633 to the solid dispersion technique to improve its solubility, absorption, and antitumor efficacy after oral ...

background: cardiovascular mortality and morbidity are high in chronic renal failure (crf) patients. increased dispersion of qt intervals is known to predispose to ventricular arrhythmias and sudden cardiac death. this study was conducted to assess the effect of hemodialysis (hd) on corrected qt (qtc) intervals and their dispersions (qtd) in chronic hemodialyzed patients. methods: fifty-eight p...

objective(s): the aim of this study was to synthesis new dental nanocomposites reinforced with fabricated glass nanoparticles and compare two methods for fabrication and investigate the effect of this filler on mechanical properties. materials and methods: the glass nanoparticles were produced by wet milling process. the particle size and shape was achieved using psa and sem. glass nanoparticle...

Despite the great potential of graphene as a nanofiller, achieving homogeneous dispersion remains the key challenge for effectively reinforcing polyolefin (such as polyethylene (PE) and polypropylene (PP)) nanocomposites. Therefore, in this research, we report a facile combined in situ polymerization and masterbatch method for fabricating PP/reduced graphene oxide (rGO) nanocomposites. In the p...

This paper presents an investigation of powder dispersion based on a combined computational fluid dynamics (CFD) and discrete element method (DEM) approach. Agglomerates of different particle sizes and polydispersities are dispersed in a cyclonic flow at different flow velocities. The analysis of flow field and agglomerate properties indicates that the dispersion is governed by two competitive ...

INTRODUCTION Hypertension and obesity in adults have been linked to increased EKG P-wave dispersion; the association has been shown in relation to hypertension, left ventricular hypertrophy and atrial enlargement. Though studies in children have linked P-wave dispersion to left ventricular hypertrophy, scant pediatric literature relates P-wave dispersion to hypertension and obesity. OBJECTIVE...

   High strength and elastic biodegradable membranes are of great demand in modern technology. Similar membranes have been developed by irradiating different weight poly (vinyl alcohol) (PVA) – hydroxypropyl guar gum (HPG) blends and followed by combining with ex situ nanosilica. Polarized light microscopic (PLM) study indicates that electron beam irradiation produced crosslinks and develop...

The principal protein component of the hyaline layer of sea urchin eggs is the calcium-insoluble protein first described by Kane and Hersh. The protein hyalin is abnormally high in acidic amino acids, almost devoid of basic amino acids, and characteristically rich in valine and proline. Essentially all of the cysteine present is found in the disulfide form; no evidence points to intermolecular ...

Article history: Received 7 April 2011 Received in revised form 17 September 2011 Accepted 18 September 2011 Is wind direction an adequate marker of air mass history? This review looks at the evolution of methods for assessing the effect of the origin and pathway of air masses on composition change and trends. The composition of air masses and how they evolve and the changing contribution of so...