We show that the Poisson–Dirichlet distribution is the distribution of points in a scale-invariant Poisson process, conditioned on the event that the sum T of the locations of the points in (0,1] is 1. This extends to a similar result, rescaling the locations by T , and conditioning on the event that T 6 1. Restricting both processes to (0, β] for 0 < β 6 1, we give an explicit formula for the ...

During the past ten years a number of papers* have been published dealing with the relationship between antisocial behaviour and electro-encephalographic abnormality. The subjects of these enquiries have ranged in degree of behavioural instability from truants to aggressive recidivists in prison, and in ages from childhood to the late forties. With one exception (Gibbs and others, 1945), the re...

Nucleotide substitutions in the HA1 domain of seasonal influenza virus H3N2 occur in temporal clusters, which was interpreted as a result of recurrent selective sweeps underlying antigenic drift. However, classical theory by Watterson suggests that episodic substitutions are mainly due to stochastic genealogy combined with unique genetic structure of influenza virus: High mutation rate over a n...

Traditional optimizing compilers are limited in the scope of their optimizations by the fact that only a sin-gle function, or possibly a single module, is available for analysis and optimization. In particular, this meansthat library routines cannot be optimized to specific calling contexts. Other optimization opportunities, exploit-ing information not available before linktime such...

The outer surface protein, OspC, is highly variable in Borrelia burgdorferi sensu stricto, the agent of Lyme disease. We have shown that even within a single population OspC is highly variable. The variation of ospA and ospC in the 40 infected deer ticks collected from a single site on Shelter Island, New York, was determined using PCR-SSCP. There is very strong apparent linkage disequilibrium ...

BACKGROUND Genetic diversity of three polymorphic markers in the phenylalanine hydroxylase (PAH) gene region including PvuII (a), PAHSTR and MspI were investigated. METHODS Unrelated individuals (n=139) from the Iranian populations were genotyped using primers specific to PAH gene markers including PvuII(a), MspI and PAHSTR. The amplified products for PvuII(a), MspI were digested using the ap...

OBJECTIVES The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. MATERIALS AND M...

A mutant gene which appeared in a finite population will eventually either be lost from the population or fixed (established) in it. The mean time until either of these alternative events takes place was studied by WATTERSON (1962) and EWENS (1963). They made use of a method previously announced by DARLING and SIEGERT (1953), and, independently by FELLER (1954). Actually, DARLING and SIEGERT re...

background: genetic diversity of three polymorphic markers in the phenylalanine hydroxylase (pah) gene region including pvu ii (a), pahstr and msp i were investigated. methods: unrelated individuals (n=139) from the iranian populations were genotyped using primers specific to pah gene markers including pvu ii(a), msp i and pahstr. the amplified products for pvu ii(a), msp i were digested using ...

When there is no recombination among nucleotide sites in DNA sequences, DNA polymorphism and fixation of mutants at nucleotide sites are mutually related. Using the method of gene genealogy, the relationship between the DNA polymorphism and the fixation of mutant nucleotide was quantitatively investigated under the assumption that mutants are selectively neutral, that there is no recombination ...