This review highlights the pharmacology, pharmacokinetics, pharmacological actions, therapeutic uses and adverse effects of cannabinoids. The effect of cannabinoids on anaesthesia is mentioned briefly. Important advances have taken place in cannabinoid research over the last few years and have led to the discovery of novel ligands. The possible clinical applications of these ligands and the dir...

Clinical application of evidence-based pharmacogenomics information has the potential to help healthcare professionals provide safe and effective medication management to patients. However, there is a gap between the advances of pharmacogenomics discovery and the health professionals' knowledge regarding pharmacogenomics testing and therapeutic uses. Furthermore, pharmacogenomics education mate...

Water demand prediction by end-use at an appropriate spatial and temporal resolution is essential for planning water supply systems that will supply water from a diversified set of sources on a fit-for-purpose basis. Understanding seasonal, daily and sub-daily water demand including peak demand by end-uses is an essential planning requirement to implement a fit-for-purpose water supply strategy...

Since independence, joint use of water resources in the Aral Sea basin has been a critical international problem between the Central Asian republics, especially in the Syr Darya basin where the tradeoffs between use of water for agricultural and energy production are very acute. Previous centralized methods of planning, formation of independent countries and the emergence of national interests ...