OBJECTIVE The study aims to investigate whether there is a higher excitability in the deep cortical layers of the peri-oral region of the somatosensory cortex as compared to other cortical regions in absence epileptic WAG/Rij rats and whether this is unique for this type of epileptic rats, as would be predicted by the cortical focus theory of absence epilepsy. METHODS Excitability of cortical...

We used sharp-electrode, intracellular recordings in an in vitro brain slice preparation to study the excitability of neocortical neurons located in the deep layers (>900 microm from the pia) of epileptic (180-210-days old) Wistar Albino Glaxo/Rijswijk (WAG/Rij) and age-matched, non-epileptic control (NEC) rats. Wistar Albino Glaxo/Rijswijk rats represent a genetic model of absence seizures ass...

Prior exposure of a vaccinee to certain species of environmental mycobacteria can prime the immune system against common mycobacterial antigens, which can in turn reduce the subsequent efficacy of live attenuated mycobacterial vaccines (such as Mycobacterium bovis BCG), in both human and livestock vaccination programs. In this study, two strains of Mycobacterium avium, both isolated from New Ze...

the experimental study and modeling of gravity drainage during water alternative gas injection, wag process, in carbonate rock for one of the iranian off-shore reservoir at lab-scale were carried out. the mechanism of gravity drainage during the wag process, and its contribution to the oil recovery in the fractured carbonate reservoirs were also studied. in the wag process alternatively gas is ...

Absence epilepsy is a generalized form of epilepsy where spike-wave discharges (SWDs) involve both hemispheres of the brain and thereby alter consciousness. Recent evidence by Meeren et al (2002) in the WAG/Rij rat model of absence epilepsy points to a cortical focus of SWDs before rapid generalization of the SWDs. This focus belongs in the peri-oral area of the somatosensory cortex, and it was...

Web-at-a-Glance (WAG) is a system to assist the user in information retrieval and discovery by gleaning the most relevant information from a web site or several web sites. This paper presents this new approach for intelligent information retrieval from web sites, and describes the prototyping of the light-weight WAG system as an active index system. q 1998 Elsevier Science B.V. All rights reser...

The aim of this study was to examine the development of cortical epileptic afterdischarges (ADs) in genetic absence epilepsy WAG/Rij rats, and to compare them with two strains with minimal incidence of spike-and-wave (SW) episodes (ACI and Wistar). Epileptic ADs were elicited by stimulation of sensorimotor cortex in 12-, 18-, and 25-day-old rats of the three strains. The threshold current inten...

OBJECTIVE Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Human patients and rat absence models show bilateral spike-wave discharges (SWD) in cortical regions. We employed diffusion tensor imaging (DTI) in rat absence models to detect abnormalities in white matter pathways connecting regions of seizure activity. METHODS We studied Wis...

This essay illustrates, by means of an analysis of the film, Wag the Dog the relationship betweenmedial hybridization and cognitive “strange loops”. As defined by Douglas Hofstadter, the‘strange loop’ is a concept rooted in the subjectivity of individual perception that integratesdifferent levels of abstraction. Applied to “intermedial” practice it provides a heuristic platformf...