conclusions our results showed that c. albicans was the most frequently isolated from both patients with vaginitis and normal individual. in the present study, we could not find any correlation between extracellular activities and sources of isolates (patients and normal flora) and sensitivity or resistance to fluconazole. background extracellular phospholipase, proteinase, and coagulase are ac...

In 1990, more than 13 million American women received prescriptions for treating vaginitis-the most common reason for visiting the gynecologist. (1) Vaginitis caused by yeast species accounts for approximately 40% of these cases, second only to bacterial vaginosis (45%). (2,3) The incidence of vulvovaginal candidiasis (VVC) has increased dramatically in the past decade. In the United Kingdom, t...

All humans are colonized with Candida species, mostly Candida albicans, yet some develop diseases due to Candida, among which genitourinary manifestations are extremely common. The forms of genitourinary candidiasis are distinct from each other and affect different populations. While vulvovaginal candidiasis affects mostly healthy women, candiduria occurs typically in elderly, hospitalized, or ...

In this metaanalysis of randomized controlled trials (RCTs) we aimed to compare the in vivo and in vitro activity and the safety of per os itraconazole and fluconazole treatment of uncomplicated acute vaginal/vulvovaginal candidiasis in nonpregnant women. We used PubMed, Scopus, Web of Science, and Cochrane Library to identify the studies that were relevant to our metaanalysis RCTs. Six RCTs we...

background and purpose: vulvovaginal candidiasis is a frequent disease affecting approximately more than %75 of all childbearing women at least once in their lifetime by overgrowth of opportunistic candida species. recurrent vulvovaginal candidiasis (rvvc) is common in otherwise healthy individuals. several risk factors were reported to contribute to rvvc susceptibility. a polymorphism in decti...

BACKGROUND Recurrent vulvovaginal candidiasis (VVC) remains a challenge to manage in clinical practice. Recent epidemiologic studies indicate that non-albicans Candida spp. are more resistant to conventional antifungal treatment with azoles and are considered as causative pathogens of vulvovaginal candidiasis. METHODS We searched PubMed and Scopus for studies that reported clinical evidence o...

The present work was designed to evaluate the in vitro and in vivo anti-Candida activity of pogostone (PO), a natural product isolated from Pogostemon cablin (Blanco) Benth. PO showed potent in vitro activity against clinical Candida spp. isolates tested in this study. PO and the reference drug voriconazole (VRC) were equally effective against all the fluconazole-resistant Candida albicans stra...