نتایج جستجو برای: vsvg protein

تعداد نتایج: 1234696  

2014
Paola Genevini Giulia Papiani Annamaria Ruggiano Lavinia Cantoni Francesca Navone Nica Borgese

VAPB is a ubiquitously expressed, ER-resident adaptor protein involved in interorganellar lipid exchange, membrane contact site formation, and membrane trafficking. Its mutant form, P56S-VAPB, which has been linked to a dominantly inherited form of Amyotrophic Lateral Sclerosis (ALS8), generates intracellular inclusions consisting in restructured ER domains whose role in ALS pathogenesis has no...

2016
Michelle E. Hung Joshua N. Leonard

Extracellular vesicles (EVs) mediate intercellular communication through transfer of RNA and protein between cells. Thus, understanding how cargo molecules are loaded and delivered by EVs is of central importance for elucidating the biological roles of EVs and developing EV-based therapeutics. While some motifs modulating the loading of biomolecular cargo into EVs have been elucidated, the gene...

Journal: :Memorias do Instituto Oswaldo Cruz 2011
Yousef Noori Alrefaei Tunika Ida Okatcha Danielle Elaine Skinner Paul James Brindley

Genome sequences for Schistosoma japonicum and Schistosoma mansoni are now available. The schistosome genome encodes ~13,000 protein encoding genes for which the function of only a minority is understood. There is a valuable role for transgenesis in functional genomic investigations of these new schistosome gene sequences. In gain-of-function approaches, transgenesis can lead to integration of ...

Journal: :The Journal of Cell Biology 2005
Burcu Hasdemir Daniel J. Fitzgerald Ian A. Prior Alexei V. Tepikin Robert D. Burgoyne

The traffic of Kv4 K+ channels is regulated by the potassium channel interacting proteins (KChIPs). Kv4.2 expressed alone was not retained within the ER, but reached the Golgi complex. Coexpression of KChIP1 resulted in traffic of the channel to the plasma membrane, and traffic was abolished when mutations were introduced into the EF-hands with channel captured on vesicular structures that colo...

2015
Jia-Shu Yang Angela B. Schmider Roy J. Soberman Victor W. Hsu Seung-Yeol Park

The Golgi complex plays a central role in the intracellular sorting of secretory proteins 1,2. Anterograde transport through the Golgi has been explained by the movement of Golgi cisternae, known as cisternal maturation 3–5. Because this explanation is now appreciated to be incomplete 6, interest has developed in understanding tubules that connect the Golgi cisternae 7–9. Here, we find that the...

2011
Arthur E. Johnson

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 195 No. 1 55–70 www.jcb.org/cgi/doi/10.1083/jcb.201103118 JCB 55 Correspondence to Arthur E. Johnson: [email protected] Abbreviations used in this paper: A, acceptor-containing sample; B, sample lacking acceptor and donor; D, donor-containing sample; DA, sample containing donor and acceptor; Ac-Lys, N-acetyl-lysine; ANB-Ly...

2010
Debora Rapaport Yevgenia Lugassy Eli Sprecher Mia Horowitz

Intracellular membrane trafficking depends on the ordered formation and consumption of transport intermediates and requires that membranes fuse with each other in a tightly regulated and highly specific manner. Membrane anchored SNAREs assemble into SNARE complexes that bring membranes together to promote fusion. SNAP29 is a ubiquitous synaptosomal-associated SNARE protein. It interacts with se...

Journal: :Developmental cell 2003
Alexander A Mironov Alexander A Mironov Galina V Beznoussenko Alvar Trucco Pietro Lupetti Jeffrey D Smith Willie J C Geerts Abraham J Koster Koert N J Burger Maryann E Martone Thomas J Deerinck Mark H Ellisman Alberto Luini

Protein transport between the ER and the Golgi in mammalian cells occurs via large pleiomorphic carriers, and most current models suggest that these are formed by the fusion of small ER-derived COPII vesicles. We have examined the dynamics and structural features of these carriers during and after their formation from the ER by correlative video/light electron microscopy and tomography. We foun...

Journal: :Cancer research 1999
J Galipeau H Li A Paquin F Sicilia G Karpati J Nalbantoglu

Direct in vivo tumor-targeting with "suicide" viral vectors is limited by either inefficient gene transfer (i.e., retroviral vectors) or indiscriminate transfer of a conditionally toxic gene to surrounding nonmalignant tissue (i.e., adenoviral vectors). Retrovectors pseudotyped with the vesicular stomatitis virus G protein (VSVG) may serve as a remedy to this conundrum. These retroviral particl...

2013
Valentina Lemma Massimo D'Agostino Maria Gabriella Caporaso Massimo Mallardo Giorgia Oliviero Mariano Stornaiuolo Stefano Bonatti

Frizzled 4 belongs to the superfamily of G protein coupled receptors. The unstructured cytosolic tail of the receptor is essential for its activity. The mutation L501fsX533 in the fz4 gene results in a new COOH-tail of the receptor and causes a form of Familial exudative vitreoretinopathy. Here we show that the mutated tail is structured. Two amphipathic helices, displaying affinity for membran...

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