Xanthine oxidase inhibitory activity has been reported from different plants such as Cinnamomum cassia, Chrysanthemum indicum, Lycopus europaeus, Polygonum cuspidatum, Acacia confuse, Coccinia grandis, Datura metel, Strychnos nux-vomica, Vitex negundo, Coccinia grandis, Vitex negundo, Fraxinus angustifolia, Pistacia lentiscus, Hyptis obtusiflora, H. lantanaefolia, Artemisia vulgaris, Caesalpini...

The title compound, C(42)H(63)O(4)P, was isolated from the leaves of Vitex negundo. Two of the tert-butyl groups are disordered over two orientations with occupancy ratios of 0.57 (1):0.43 (1) and 0.67 (1):0.33 (1). Several intra-molecular C-H⋯O inter-actions are observed in the mol-ecular structure.

Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, negundonorins A (3) and B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and c...

The use of conventional drugs for the treatment pain and inflammation has largely resulted in various side effects. These challenges have triggered search alternative therapy such as herbal medication that may serve a safe, effective, alternate approach to managing inflammation. Vitex negundo, potential lipophilic molecule, possesses limited solubility permeability. Emulgels are either water-in...

The antibacterial activity of the leaves of Vitex negundo was tested against three bacteria Viz., Staphylococcus aureus Escherichia coli and Klebsiella Peumoniae, The fresh aqueous, heated aqueous extract, chloroform and methanolic extract of leaves were used for screening their antibacterial potential. The fresh and aqueous extracts of leaves in various dilutions were found to have antibacteri...

A high performance liquid chromatography coupled with photodiode array detection method was developed for the identification and quantification of p-hydroxy benzoic acid and agnuside in the extracts of Vitex negundo and Vitex trifolia. The separation was achieved using acetonitrile and O-phosphoric acid-water (0.5%, v/v) as the mobile phase in an isocratic elution mode. Mean retention times of ...

The use of Vitex negundo Linn. (Family: verbenaceae) is well documented in ayurveda and traditional Indian system of medicine for variety of diseases and liver ailments. The aim of the study was to investigate liver protective efficacy of a standardized bioactive fraction (SF) from Vitex negundo Linn. against acetaminophen (APAP) and galactosamine (GalN) hepatotoxicity. SF was tested at doses 1...