Aims: In this research, it was aimed to determine the phenolic components of Vitex agnus‐castus L. (Chaste) samples belonging Verbenaceae family, which is one significant medicinal plants our country.Methods and Results: agnus-castus leaf flower provided from during flowering grown under Karabörtlen area (81 m) ecological conditions. Samples were then dried in a semi-shadowy airy place at room ...

Seven new labdane-type diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg...

Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, ...

Vitex agnus-castus L. (chaste-berry). Phytomedicine. 2004 Jan;11(1):18-23. Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. Department of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illi...

medical therapies have been widely used for premenstrual syndrome (pms), but in all of them side effects are predominant. herbal remedies rarely have side effects and people have more tendencies toward them than chemical therapies. in this study the therapeutic effect of vitex agnus castus on women who had the pms, in comparison with placebo, were investigated. in this randomized, placebo-contr...

Cyclic mastalgia of varying intensity occurs every month in at least 70% women, persistent pain the mammary glands moderate and severe degree is occur about 50% patients with benign mastopathy. The cause mastodynia morphofunctional rearrangement glandular stromal components tissues expansion ducts proliferation epithelial structures due to a lack progesterone an increase prolactin levels. Thera...

Background. Primary dysmenorrhea (PD) is one of the most common types gynecological pathology and observed in 31–52% young women, 10% them pain so intense that leads to disability. In pathogenesis PD consider a representative eicosanoids— thromboxane A2 with pronounced vasoconstrictor effect. The article presents results clinical hormonal examination women developed on this basis method treatme...

Many women with PMS use alternative therapies, although there has been little research to demonstrate their efficacy. This systematic review provides a comprehensive discussion of dietary supplements and herbal remedies commonly used for premenstrual syndrome (PMS), including calcium, magnesium, vitamin B6, evening primrose oil, Vitex agnus castus, ginkgo biloba and St John’s Wort. Randomized c...