Faktor – faktor keselamatan dan kesehatan kerja (K3) sangat berpengaruh terhadap kinerja dari sebuah proyek, sehingga harus diperhatikan dengan sungguh sungguh. Pengabaian tersebut terbukti mengakibatkan tingginya tingkat kecelakaan pada proyek konstruksi. Sehingga akan menambah biaya asuransi tenaga mempengaruhi proyek. Tahapan penelitian ini adalah studi berbagai literatur yang ada untuk mene...

Bit merupakan sumber vitamin C selain itu, bit juga banyak mengandung senyawa antimikrobia dan antioksidan yang mampu menghambat sel-sel tumor. Penelitian ini bertujuan untuk mengetahui aktivitas mutu probiotik dihasilkan potensi ekstak buah sebagai bahan subtitusi susu dalam pembuatan yoghurt. dilakukan di Laboratorium Teknologi Pengolahan Pangan, Program Studi Hasil Pertanian, Fakultas Univer...

We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-naphthoquinone (VK3-OCH(3)) showed...

BACKGROUND Lack of receptor tyrosine kinase (TrkA), a high-affinity nerve growth factor (NGF) receptor, is closely associated with the malignant progression of neuroblastoma (NB) and its prognosis. Vitamin K3 (VK3) analogs inhibit the activity of protein tyrosine phosphatases (PTPases), which causes hydrolysis of the phosphate groups bound to the tyrosine residues on tyrosine kinase, resulting ...

Vitamin K group is known as an anti-haemorrhagic vitamin and has a common skeleton of 2-methyl-1,4-naphthoquinone. There are several homologs which differ in the alkyl side chain at 3-position of naphthoquinone ring. Of these homologs, vitamin K2(20) (K2) which has a geranyl-linalyl side chain is considered to be a physiologically active type of this vitamin, since Martius, et al.2) reported th...

A number of life’s key biochemical processes, including blood coagulation, bone metabolism and cell growth, are mediated by a family of natural products referred to as the K vitamins [1]. Much work has been carried out in recent times to elucidate the mechanisms by which these compounds elicit their activity, and a number of proteins that are vitamin K-dependent have been identified in a variet...