The case described by Dr. Sarper and her colleagues in their letter to the editor, entitled “Severe iron defi ciency anemia due to late presentation of congenital diaphragmatic hernia in a toddler”, was not a late but rather a delayed diagnosis case since iron defi ciency anemia was diagnosed in this patient at least a year earlier with intermittent vomiting [1]. The diagnosis of a diaphragmati...

Despite aggressive treatment and screening efforts, breast cancer remains the second leading cause of cancer-related deaths among women in the United States (1). Because of the large number of women dying from this disease and the toxicity of breast cancer treatments, recent efforts have focused on identifying effective cancer preventive agents. These efforts have led to the development of anti...

292 www.thelancet.com Vol 382 July 27, 2013 Iodine, a crucial micronutrient, is essential for thyroid hormone production and for normal in-utero neurodevelopment. During pregnancy, iodine intake must be increased by 50% because of physiological increases in maternal thyroid hormone production, an increase in maternal renal iodine losses, and fetal iodine needs for thyroid hormone production. Io...

JEZDINSKÝ ALEŠ, POKLUDA ROBERT, SLEZÁK KATALIN. 2016. Eff ect of Nutrient Supply on Some Selected Parameters of Sweet Pepper (Capsicum annuum L. cv. ‘HRF’) Transplants. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 64(2): 455–460. In the trial the eff ect of nitrogen defi ciency and potassium surplus on the dry weight, photosynthetic activity (A), transpiration (E), st...

www.thelancet.com Vol 381 March 2, 2013 717 The story of Basil Hetzel’s fi ght against iodine defi ciency begins in 1964, in the highland villages of Papua New Guinea. A medical scientist with an interest in thyroid disorders, Hetzel had been invited by the country’s Public Health Department to investigate the goitre and cretinism that was prevalent in the mountain communities. Witnessing the s...

Lesions of the peripheral nervous system have been recognized and described in animals fed diets deficient in the antineuritic vitamin B, but there has been relatively little written about nervous system lesions in association with diets deficient in vitamin A. Hart , Miller and McCollum (1) described histologic changes "not unlike those recorded for beri-beri" in the nervous system of swine fe...

Pompe disease is a rare autosomal recessive lysosomal storage disease caused by defi ciency of acid α-glucosidase (GAA). This defi ciency results in glycogen accumulation in the lysosomes, leading to lysosomal swelling, cellular damage, and organ dysfunction. In early onset patients (the classic infantile form), this glycogen accumulation leads to death, usually before the age of 1 year. Some p...