نتایج جستجو برای: virotherapy

تعداد نتایج: 1060  

Journal: :Zeitschrift für Angewandte Mathematik und Physik 2022

This paper is concerned with the global boundedness of an oncolytic virotherapy model fusogenic virus and syncytia. It proved that a related problem has unique bounded classic solution under proper conditions. Our work partially extend some previous results.

Journal: :Cancer research 2009
Leticia R Paiva Christopher Binny Silvio C Ferreira Marcelo L Martins

One of the most promising strategies to treat cancer is attacking it with viruses. Oncolytic viruses can kill tumor cells specifically or induce anticancer immune response. A multiscale model for virotherapy of cancer is investigated through simulations. It was found that, for intratumoral virus administration, a solid tumor can be completely eradicated or keep growing after a transient remissi...

2014
Mikiya Ishihara Naohiro Seo Jun Mitsui Daisuke Muraoka Maki Tanaka Junichi Mineno Hiroaki Ikeda Hiroshi Shiku

Oncolytic virotherapy combined with immunomodulators is a novel noninvasive strategy for cancer treatment. In this study, we examined the tumoricidal effects of oncolytic HF10, a naturally occurring mutant of herpes simplex virus type-1, combined with an agonistic DTA-1 monoclonal antibody specific for the glucocorticoid-induced tumor necrosis factor receptor. Two murine tumor models were used ...

Journal: :Cancer research 2012
Diana M Rommelfanger Phonphimon Wongthida Rosa M Diaz Karen M Kaluza Jill M Thompson Timothy J Kottke Richard G Vile

Oncolytic virotherapy offers the potential to treat tumors both as a single agent and in combination with traditional modalities such as chemotherapy and radiotherapy. Here we describe an effective, fully systemic treatment regimen, which combines virotherapy, acting essentially as an adjuvant immunotherapy, with adoptive cell transfer (ACT). The combination of ACT with systemic administration ...

2015
Eike Binz Ulrich M Lauer

Oncolytic virotherapy has made significant progress in recent years, however, widespread approval of virotherapeutics is still limited. Primarily, this is due to the fact that currently available virotherapeutics are mostly tested in monotherapeutic clinical trials exclusively (ie, not in combination with other therapies) and so far have achieved only small and often clinically insignificant re...

Journal: :Acta biochimica et biophysica Sinica 2005
Xin-Yuan Liu Jing-Fa Gu Wen-Fang Shi

Gene therapy and viral therapy for cancer have therapeutic effects, but there has been no significant breakthrough in these two forms of therapy. Therefore, a new strategy called "targeting gene-virotherapy", which combines the advantages of gene therapy and viral therapy, has been formulated. This new therapy has stronger antitumor effects than either gene therapy or viral therapy. A tumor-spe...

2016
Kaname Nosaki Katsuyuki Hamada Yuto Takashima Miyako Sagara Yumiko Matsumura Shohei Miyamoto Yasuki Hijikata Toshihiko Okazaki Yoichi Nakanishi Kenzaburo Tani

Although various therapies are available to treat cancers, including surgery, chemotherapy, and radiotherapy, cancer has been the leading cause of death in Japan for the last 30 years, and new therapeutic modalities are urgently needed. As a new modality, there has recently been great interest in oncolytic virotherapy, with measles virus being a candidate virus expected to show strong antitumor...

Journal: :Molecular therapy : the journal of the American Society of Gene Therapy 2006
David A. Williams Robert M. Frederickson Inder M. Verma Barrie J. Carter Kenneth Cornetta Charles Coutelle Theodore Friedmann George Karpati David Kirn Donald B. Kohn Pedro Lowenstein Katherine Ponder David Russell John J. Rossi R. Jude Samulski

Journal: :Biomedicines 2021

As new treatment modalities are being explored in neuro-oncology, viruses emerging as a promising class of therapeutics. Virotherapy consists the introduction either wild-type or engineered to site disease, where they exert an antitumor effect. These can be non-lytic, which case used deliver gene therapy, lytic, induces tumor cell lysis and subsequent host immunologic response. Replication-comp...

2017
Gregory K. Friedman James M. Markert George Yancey Gillespie

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