Viral hepatitis remains a significant worldwide threat, in spite of the availability of several successful therapeutic and vaccination strategies. Complications associated with acute and chronic infections, such as liver failure, cirrhosis and hepatocellular carcinoma, are the cause of considerable morbidity and mortality. Given the significant burden on the healthcare system caused by viral he...

Viral infections have become an increasingly worsening threat, SARS-Cov-2 is the third coronavirus that emerged during past twenty years. The contagion can also occur by inhalation of aerosolized viruses, capable floating in air for long times (in closed spaces) and traveling unknown distances. A lesson from history shows exclusive infectious disease hospitals with multiple building are still a...

To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.

Arboviral diseases are a major threat to human and animal health today. Analysis of whole-genome sequences of decades-old arboviral strains may bring new insights into the viral evolution that might have facilitated outbreaks. Here, we report the whole-genome sequences of two Middelburg viruses isolated several decades ago in the Central African Republic.

The overall threat of a viral pathogen to human populations is largely determined by the modus operandi and velocity of the pathogen that is transmitted among humans. Microorganisms that can spread by aerosol are considered a more challenging enemy than those that require direct body-to-body contact for transmission, due to the potential for infection of numerous people rather than a single ind...

Abstract Viral infection is a key limiting factor to cucurbit production globally. The viral population within Australia differs from that elsewhere in the world it represented by relatively few pathogens small number of virus families. infections induce range physical deformities and discoloration on leaves fruit commodities. Typically, result decline marketable yield even plant death extreme ...

Viral infections represent a major threat to human health and the global economy; however, most of currently available antiviral drugs are not fully effective in restricting viral replication selecting for drug-resistant variants. Targeted protein degradation technologies promising strategies avoid or delay emergence drug resistance. Among degradation-based multi-specific approaches, proteolysi...

The H1N1 influenza virus is a serious threat to human population. Oseltamivir and Zanamivir are known antiviral drugs for swine flu with observed side effects. These drugs are viral neuraminidase and hemagglutinin inhibitor prevents early virus multiplication by blocking sialic acid cleavage on host cells. Therefore, it is of interest to identify naturally occurring novel compounds to control v...

The current pandemic caused by the new influenza A(H1N1) virus of swine origin and the current pandemic threat caused by the highly pathogenic avian influenza A viruses of the H5N1 subtype have renewed the interest in the development of vaccines that can induce broad protective immunity. Preferably, vaccines not only provide protection against the homologous strains, but also against heterologo...