Studies of human immunodeficiency virus (HIV) vaccines in animal models suggest that it is difficult to induce complete protection from infection (sterilizing immunity) but that it is possible to reduce the viral load and to slow or prevent disease progression following infection. We have developed an age-structured epidemiological model of the effects of a disease-modifying HIV vaccine that in...

BACKGROUND: This study was conducted to determine the characteristics of various viral respiratory pathogens spreading during epidemic season 20212022 and frequency co-infection with SARS-CoV-2 influenza.
 AIM: To assess development influenza cases in patients acute infections between 2021 2022.
 MATERIALS AND METHODS: Traditional hospital epidemiological surveillance methods for were...

Porcine epidemic diarrhea is a devastating swine enteric disease, which is caused by porcine epidemic diarrhea virus (PEDV) infection. Our studies demonstrated that PEDV infection resulted in the up-regulation of proinflammatory cytokines. Meanwhile, PEDV infection and overexpression of viral nucleoprotein resulted in the acetylation and release of high mobility group box 1 proteins in vitro, a...

We evaluated different approaches for diagnosing measles virus (MV) infection in unvaccinated children and in healthy contact persons (n=194) during a measles epidemic in The Netherlands. MV RNA was detected by reverse-transcriptase polymerase chain reaction in throat-swab specimens from 93% of the patients with clinical symptoms. MV RNA was detected from 5 days before until 12 days after the o...

An epidemic model with optimal control strategies was investigated for Hepatitus C Viral disease that can be transmitted through infected individuals. In this study, we used a deterministic compartmental model for assessing the effect of different optimal control strategies for controlling the spread of Hepatitus C disease in the community. Stability theory of differential equations is us...

Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area infect humans. To explore potential threat of HV WENV public health safety, an environmental laboratory investigation was conducted 2020–2021, Jiangxi province, China. A total 461 small mammals 7 species paired sera from 43 suspected HFRS cases were...

Human immunodeficiency virus (HIV) infection includes acute, early, chronic, and late stages. Acute HIV infection lasts approximately 3 weeks and early HIV infection, which includes acute HIV infection, lasts approximately 7 weeks. Many testing and blood screening algorithms detect HIV antibodies about 3 weeks after HIV infection. Incidence estimates are based on results of modeling, cohort stu...

UNLABELLED During the dengue virus type 3 (DENV-3) epidemic that occurred in Havana in 2001 to 2002, severe disease was associated with the infection sequence DENV-1 followed by DENV-3 (DENV-1/DENV-3), while the sequence DENV-2/DENV-3 was associated with mild/asymptomatic infections. To determine the role of the virus in the increasing severity demonstrated during the epidemic, serum samples co...

Herpes is one of the most common uncontrolled human viral infections. Despite fact that herpes has been known for more than 2000 years, only in last decade a real possibility organizing effective therapy appeared. Some infected individuals may have mild symptoms form fever, adenopathy, or general infectious manifestations. Usually, HSV1 infection not epidemic and occurs sporadically. In 20-40% ...

It is a perfect storm for the chronic viral infection associated with the greatest morbidity and mortality in the United States. Of the ≥3 million Americans infected with hepatitis C virus (HCV), only ≤50% know they are infected. Infections acquired many years ago from parenteral exposures—injection drug use, transfusions received before screening assay availability (in 1992), or other healthca...