background and aims: dna constructs containing hcv antigens have become one of the vaccine candidates for induction of anti-hcv cellular and humoral immunity. in this study, we constructed a novel expressing vector harboring a fusion sequence derived from an overlapping fragment in the middle of ns3 and a truncated core fragment to avoid troubles reported to be associated with full gene express...

1. Distinguish among viral hepatitis A, B, C, D, and E’s virology, epidemiology, and serological response to infection and clinical manifestation. 2. Design a prophylactic and therapeutic plan identifying the risk factors associated with the transmission of viral hepatitis A, B, C, D, or E in a clinical situation. 3. Develop an appropriate prophylactic regimen for preventing viral hepatitis A, ...

Background: Viral load and alanine aminotransferase (ALT) levels may not be the key points for making a decision in the treatment of anti-HBe positive chronic hepatitis B. The purpose of this study was to assess the histological evaluation of liver to find the need for treatment on 72 patients with anti-HBe positive chronic hepatitis B. Methods: The liver biopsy slides of the 72 patients (56 s...

conclusions our findings indicate that patients with the homozygous cc genotype in the il28b gene had a significantly higher rate of response to treatment than those with the tt or ct genotypes. nor does the il28b rs12979860 polymorphism affect the viral load. results the genotype frequencies of rs12979860 polymorphism in group 1 were cc (28.9%), ct (37.8%) and tt (33.3%) and in group 2 were cc...

Two antigen-antibody systems were Out of 42 sera from patients with acute viral hepatitis 33 were positive for HBsAg,all HBsAg positive individuals possessed anti-HBc. From 11 blood donors  sera 8 were positive for HBsAg and 9 were Positive for anti-HBc;2 leprosy sera were tested,both of them were positive for HBsAg and anti-HBc. 5 miscellaneous sam­ples,z·were positive for HBsAg and anti-HBc...

Today, chronic viral hepatitis is considered as a public health problem in the world. Totally, 5% of the world population, especially in Asia and Africa suffer from this problem. The prevalence of acute hepatitis in America is 0.1-0.2 percent, 50% of those with hepatitis C (HCV) and 5-10% of them with hepatitis B (HCV) develop chronic hepatitis. Determining HBV and HCV genotypes is important to...

Abstract Background: Distribution of hepatitis C virus genotypes varies geographically and can be associated with clinical aspects. The virus has six major genotypes and eleven sub-genotypes. According to the recent studies, in hepatitis C patients, treatment duration and ribavirin dosage should be determined based on the type of virus genotype. Be...

background previous studies using pegylated interferon (peg-ifn) and ribavirin (rbv) combination therapy suggested that patients with hepatitis c virus (hcv) genotype 1 and low pretreatment hcv rna level who achieved rapid virological response (rvr) can be treated for 24 weeks without compromising sustained virological response (svr) rate. objectives the current study aimed to investigate the e...