The paper presents a service composition language called VINCA, which differs from many existing ones in its emphasis on enabling business users to visually “program” from business view-point their personalized applications on the basis of Web-based services. VINCA embodies an integrated approach to mediating between diverse, rapidly changing user requirements and composites of individual servi...

Chemotherapy induced peripheral neuropathy (CIPN), a side effect of many anti-cancer drugs including the vinca alkaloids, is characterized by a severe pain syndrome that compromises treatment in many patients. Currently there are no effective treatments for this pain syndrome except for the reduction of anti-cancer drug dose. Existing data supports the model that the pain associated with CIPN i...

The suitability of neurons of the freshwater snail Lymnaea stagnalis as a test system for the neurotoxic side effects of antitumour Vinca alkaloids has been investigated, by studying the process of paracrystal induction by Vinca antitumour agents. Three Vinca alkaloids have been compared: the natural vinblastine and vincristine and the semisynthetic vindesine. They appear to induce two types of...

Vinca alkaloids are well known for their antimitotic and antitumor activities. It inhibits transcription and translation 0, 2, 3). Vinca alkaloids cause specific mitotic arrest of cells. The drugs derived from these alkaloids are: Vinblastine and vincrystine. These drugs have been extensively used for studying the nature of cell arrest and the associated changes in various clinical (neoplastic ...

Microtubules (MTs) are key components of the cytoskeleton for all eukaryotes and are vital for cellular processes such as mitotic spindle formation, intracellular transport, vesicle formation, cellular signaling, and migration. These functions depend on the dynamic nature of MTs, which arises from the polymerization and depolymerization events of individual heterodimers, made up of αand β-tubul...

\Ve have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by means of their effects on mitotic spindle microtubules or by another mechanism or by a combination of mechanisms. Five Vìnca alkaloids were used to investigate the relationship in Urla cells between inhibition of cell proliferation and blockage of mitosis, alteration o...

Vinca major L. is an evergreen perennial weed of family Apocynaceae, growing naturally in hilly areas Hazara region Khyber Pakhtunkhwa, Pakistan. Flowers this were collected from Khanspur, Ayubia during June 2021, shade dried and extracted pure methanol for two weeks. After filtration, the extract was analyzed by GC-MS identification possible bioactive compounds. ?-Amyrin compounds (32.49%) fol...

The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate ...

The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate ...

During a phase I trial of EC145 (a folate-targeted vinca alkaloid conjugate), constipation was identified as the dose-limiting toxicity, probably from a nonfolate receptor-related liver clearance process capable of releasing unconjugated vinca alkaloid from EC145 and shuttling it to the bile. Here, we report on the selective placement of novel carbohydrate segments (1-amino-1-deoxy-glucitolyl-γ...