Groucho (Gro) is a Drosophila corepressor required by numerous DNA-binding repressors, many of which are distributed in gradients and provide positional information during development. Gro contains well-conserved domains at its N- and C-termini, and a poorly conserved central region that includes the GP, CcN, and SP domains. All lethal point mutations in gro map to the conserved regions, leadin...

Growth-related oncogene (GRO)-β, or chemokine (C-X-C motif) ligand 2 (CXCL2), is a member of the CXC chemokine family that may mediate various functions, including attracting neutrophils to sites of inflammation, and participating in tumorigenesis and progression. However, the expression of GRO-β in colorectal cancer (CRC) and the association with the clinical outcome of the disease remains poo...

We provide a framework and evidence to confront two questions: Does the location of an establishment shape its adoption of different complex Internet applications even when controlling for an industry’s features? If location does matter, what features in an industry shape whether Internet adoption follows a pattern consistent with the urban leadership or global village hypotheses? Our findings ...

While many pundits sing the praises of the coming global village, Talbott wants us to examine their unspoken assumptions. Many seem to be saying that simple technological tools can guarantee freedom and privacy, make learning and personal growth easy, and build strong democratic communities. Talbott sees this as wishful thinking—magical, automatic solutions to complex human problems. He sees th...

BACKGROUND RNA interference technology has shown high therapeutic potential for cancer treatment. However, serum instability, poor tissue permeability and non-specific uptake of short interfering RNA (siRNA) limit its administration in vivo. To overcome these limitations and improve the specificity for ovarian cancer, we developed a targeted nanoparticle delivery system for siRNA. This system i...

Over the past three decades and most recently, information and communications technologies (ICTs) have orchestrated obvious fundamental changes in the way mankind organises himself and does his own things, rendering the world into one digital global village. The greatest casualty in the mist of all these changes is the educational system, because the development, acquisition and dissemination o...

The chemokine GRO-alpha (CXCL1) has been found to mediate the proliferation of glia progenitor cells during neural development. As malignant gliomas are thought to arise from glia progenitors or their differentiated counterparts, astrocytes or oligodendrocytes, we have investigated whether GRO-alpha regulates the tumor characteristics of glioma cells. We found first that resected glioma specime...

We show that the model proposed by Esin, McClintock, & Narayan for the low state, intermediate state, and high state of the black hole soft X-ray transient, Nova Muscae 1991, is consistent with the spectral evolution of the black hole X-ray binary, Cyg X-1, during the hard-to-soft state transition observed in 1996. We also apply the model to the outbursts of two other black hole X-ray transient...

BACKGROUND Growth-related oncogene- (GRO-) β is a member of the CXC chemokine family, which may mediate various functions, such as attracting neutrophils to sites of inflammation, regulating angiogenesis, and participating in tumorigenesis and progression. However, the expression of GRO-β in ovarian cancer and its relationship to the clinical characteristics of this disease remain poorly unders...

Epithelial-stromal interactions play a critical role in tumor initiation and progression; cancer-associated stroma, but not normal stroma, is known to be tumor-promoting. However, the molecular signal used by epithelial cancer cells to reprogram normal stroma to a tumorigenic stroma is not known. Here, we present evidence to suggest that the chemokine growth-regulated oncogene 1 (Gro-1) may be ...