Background: during natural aging, cellular and molecular changes in the colonic mucosa contribute to chronic damage development of various neoplasia, including colorectal cancer (CRC). Aim: assess age peculiarities mRNA expression samples normal from parts colon. Patients Methods: study included 95 patients. Normal biopsies were derived videocolonoscopy different colon, i.e., right colon (n=91)...

background: hydatidosis is one of the cosmopolitan parasitic zoonoses caused by the larval stage of echinococcus granulosus. diagnosis of hydatidosis is still an unresolved problem. serological tests using crude antigens for diagnosis of e. granulosus are sensi-tive, however their specificity are not satisfactory. therefore, who recommended spe-cific serological methods using specific antigens,...

Data have been presented (2-4) indicating that anti AKR/J leukemia sera prepared in Dutch rabbits previously made tolerant to normal whole unfractionated AKR/J cells has little mouse toxicity, but marked toxicity for spontaneous AKR/J leukemia. Using precipitin reactions, attempts to correlate in vivo and in vitro activity of heterologous tolerant antisera against mouse tumors have failed [Ref....

Methylation abnormalities of cancer-related genes are recognized to play an important role in carcinogenesis. Methylenetetrahydrofolate reductase (MTHFR) regulates DNA methylation by affecting synthesis of S-adenosylmethionine, which is a universal methyl donor for methylation reactions. MTHFR gene polymorphisms that affect enzymatic activity may be associated with DNA methylation and cancer su...

12 Abstract 13 Purpose To determine the repeatability of mesopic high14 contrast (HC) and low-contrast (LC) visual acuity (VA) mea15 surements made at distance and near in healthy young indi16 viduals. While the repeatability of photopic VA is well17 known, there is a lack of information with regard to the 18 repeatability of VA measured under low luminance 19 conditions. 20 Methods In two diff...

B ASHING TRADITIONAL APPROACHES TO STRATEGIC planning has become the favoured past-time of leading business authors on both sides of the Atlantic. The litany of indictments against the types of planning processes in place at most large multinational firms is long, and often difficult to disagree with. Traditional processes have choked initiative and favoured incremental over substantive change....

We describe principles for cortical development which may apply both 5 to the evolution of species, and to the antenatal development of the cortex of indi6 viduals. Our account depends upon the occurrence of synchronous oscillation in the 7 neural field during embryonic development, and the assumption that synchrony is 8 linked to cell survival during apoptosis. This leads to selection of array...

BACKGROUND Prescription drug abuse in Southwest Virginia is a serious problem affecting indi-viduals, families, and communities. The aim of this study was to characterize and understand the extent of the prescription drug abuse problem in Southwest, Virginia as well as the dynamics that surround that abuse. More specifically, the study focused on learning the extent of the problem along with wh...

I have read the study by Nicholl et al 1 published in CHEST (June 2012) with a particular interest. The research ers have analyzed the home sleep monitoring data of 254 indi viduals with some degree of renal dysfunction (75 on hemodialysis). They have concluded that a decreased kidney function is associated with greater prevalence of obstructive sleep apnea (OSA) and nocturnal hypoxia. It is we...

background and objective : restless legs syndrome (rls) is a sensorimotor disorder that causes sleep deprivation. rls is characterized by discomfort in the legs and severe desire to move them during sleep. different prevalence rates about rls are reported in iran. this systematic review and meta-analysis was performed to estimate the prevalence of rls in iran. materials and methods : by searchi...