ALTURA, BURTON M., D. MALAVIYA, CHARLES F. REICH, AND LOUIS R. ORKIN. Effects of vasoactive agents on isolated human umbilical arteries and veins. Am. J. Physiol. 222(Z): 345-355. 1972.In vitro experiments, using both helically and longitudinally cut human umbilical arteries and veins (HUAV), were designed to determine: I) whether any of the known circulating vasoactive substances can induce co...

Cardiac ultrasound investigation of 68 prospectively studied patients with histologically proven midgut carcinoid tumors showed right heart disease in 66%. The abnormal findings included morphologic and functional aberrations of the tricuspid valve in 52% and 83%, respectively, right atrial and ventricular enlargement in 53% and 30%, and paradoxical systolic septal contractions in 19%. The pati...

The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggrega...